Cicatricial pemphigoid of the oropharynx after allogeneic stem cell transplantation for relapsed follicular lymphoma

Yoshinobu Aisa, Takehiko Mori, Tomonori Nakazato, Rie Yamazaki, Jun Yamagami, Masayuki Amagai, Yasuo Ikeda, Shinichiro Okamoto

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7 Citations (Scopus)

Abstract

A 44-year-old woman with refractory follicular lymphoma underwent allogeneic stem cell transplantation (SCT) and achieved complete remission. Grade III acute graft-versus-host disease (GVHD) developed on day 23, but no chronic GVHD occurred. The patient developed severe erosion with bullous lesions in the oral cavity 18 months after SCT. At that time, the lymphoma remained in complete remission, and she had no clinical or laboratory findings suggesting chronic GVHD. A biopsy of the oral mucosa showed moderate lymphoplasmacytic infiltration and subepidermal bullae, and direct immunofluorescence staining demonstrated linear deposition of C3 at the dermo-epidermal junction. An immunoblotting assay using human epidermal extracts confirmed the presence in her serum of an antibody against the 230-kd bullous pemphigoid antigen 1 (BPAG1). A diagnosis of cicatricial pemphigoid (CP) was made, and complete resolution of the CP was achieved with prednisolone therapy. The occurrence of autoimmune blistering diseases is rare after allogeneic SCT.

Original languageEnglish
Pages (from-to)266-269
Number of pages4
JournalInternational Journal of Hematology
Volume82
Issue number3
DOIs
Publication statusPublished - 2005 Oct

Fingerprint

Benign Mucous Membrane Pemphigoid
Follicular Lymphoma
Oropharynx
Stem Cell Transplantation
Graft vs Host Disease
Blister
Direct Fluorescent Antibody Technique
Mouth Mucosa
Prednisolone
Immunoblotting
Autoimmune Diseases
Mouth
Lymphoma
Staining and Labeling
Biopsy
Antibodies
Serum
Therapeutics

Keywords

  • Allogeneic stem cell transplantation
  • Autoantibody
  • Autoimmune blistering disease
  • Cicatricial pemphigoid
  • Graft-versus-host disease

ASJC Scopus subject areas

  • Hematology

Cite this

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title = "Cicatricial pemphigoid of the oropharynx after allogeneic stem cell transplantation for relapsed follicular lymphoma",
abstract = "A 44-year-old woman with refractory follicular lymphoma underwent allogeneic stem cell transplantation (SCT) and achieved complete remission. Grade III acute graft-versus-host disease (GVHD) developed on day 23, but no chronic GVHD occurred. The patient developed severe erosion with bullous lesions in the oral cavity 18 months after SCT. At that time, the lymphoma remained in complete remission, and she had no clinical or laboratory findings suggesting chronic GVHD. A biopsy of the oral mucosa showed moderate lymphoplasmacytic infiltration and subepidermal bullae, and direct immunofluorescence staining demonstrated linear deposition of C3 at the dermo-epidermal junction. An immunoblotting assay using human epidermal extracts confirmed the presence in her serum of an antibody against the 230-kd bullous pemphigoid antigen 1 (BPAG1). A diagnosis of cicatricial pemphigoid (CP) was made, and complete resolution of the CP was achieved with prednisolone therapy. The occurrence of autoimmune blistering diseases is rare after allogeneic SCT.",
keywords = "Allogeneic stem cell transplantation, Autoantibody, Autoimmune blistering disease, Cicatricial pemphigoid, Graft-versus-host disease",
author = "Yoshinobu Aisa and Takehiko Mori and Tomonori Nakazato and Rie Yamazaki and Jun Yamagami and Masayuki Amagai and Yasuo Ikeda and Shinichiro Okamoto",
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T1 - Cicatricial pemphigoid of the oropharynx after allogeneic stem cell transplantation for relapsed follicular lymphoma

AU - Aisa, Yoshinobu

AU - Mori, Takehiko

AU - Nakazato, Tomonori

AU - Yamazaki, Rie

AU - Yamagami, Jun

AU - Amagai, Masayuki

AU - Ikeda, Yasuo

AU - Okamoto, Shinichiro

PY - 2005/10

Y1 - 2005/10

N2 - A 44-year-old woman with refractory follicular lymphoma underwent allogeneic stem cell transplantation (SCT) and achieved complete remission. Grade III acute graft-versus-host disease (GVHD) developed on day 23, but no chronic GVHD occurred. The patient developed severe erosion with bullous lesions in the oral cavity 18 months after SCT. At that time, the lymphoma remained in complete remission, and she had no clinical or laboratory findings suggesting chronic GVHD. A biopsy of the oral mucosa showed moderate lymphoplasmacytic infiltration and subepidermal bullae, and direct immunofluorescence staining demonstrated linear deposition of C3 at the dermo-epidermal junction. An immunoblotting assay using human epidermal extracts confirmed the presence in her serum of an antibody against the 230-kd bullous pemphigoid antigen 1 (BPAG1). A diagnosis of cicatricial pemphigoid (CP) was made, and complete resolution of the CP was achieved with prednisolone therapy. The occurrence of autoimmune blistering diseases is rare after allogeneic SCT.

AB - A 44-year-old woman with refractory follicular lymphoma underwent allogeneic stem cell transplantation (SCT) and achieved complete remission. Grade III acute graft-versus-host disease (GVHD) developed on day 23, but no chronic GVHD occurred. The patient developed severe erosion with bullous lesions in the oral cavity 18 months after SCT. At that time, the lymphoma remained in complete remission, and she had no clinical or laboratory findings suggesting chronic GVHD. A biopsy of the oral mucosa showed moderate lymphoplasmacytic infiltration and subepidermal bullae, and direct immunofluorescence staining demonstrated linear deposition of C3 at the dermo-epidermal junction. An immunoblotting assay using human epidermal extracts confirmed the presence in her serum of an antibody against the 230-kd bullous pemphigoid antigen 1 (BPAG1). A diagnosis of cicatricial pemphigoid (CP) was made, and complete resolution of the CP was achieved with prednisolone therapy. The occurrence of autoimmune blistering diseases is rare after allogeneic SCT.

KW - Allogeneic stem cell transplantation

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KW - Cicatricial pemphigoid

KW - Graft-versus-host disease

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