Cicatricial pemphigoid of the oropharynx after allogeneic stem cell transplantation for relapsed follicular lymphoma

Yoshinobu Aisa, Takehiko Mori, Tomonori Nakazato, Rie Yamazaki, Jun Yamagami, Masayuki Amagai, Yasuo Ikeda, Shinichiro Okamoto

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7 Citations (Scopus)

Abstract

A 44-year-old woman with refractory follicular lymphoma underwent allogeneic stem cell transplantation (SCT) and achieved complete remission. Grade III acute graft-versus-host disease (GVHD) developed on day 23, but no chronic GVHD occurred. The patient developed severe erosion with bullous lesions in the oral cavity 18 months after SCT. At that time, the lymphoma remained in complete remission, and she had no clinical or laboratory findings suggesting chronic GVHD. A biopsy of the oral mucosa showed moderate lymphoplasmacytic infiltration and subepidermal bullae, and direct immunofluorescence staining demonstrated linear deposition of C3 at the dermo-epidermal junction. An immunoblotting assay using human epidermal extracts confirmed the presence in her serum of an antibody against the 230-kd bullous pemphigoid antigen 1 (BPAG1). A diagnosis of cicatricial pemphigoid (CP) was made, and complete resolution of the CP was achieved with prednisolone therapy. The occurrence of autoimmune blistering diseases is rare after allogeneic SCT.

Original languageEnglish
Pages (from-to)266-269
Number of pages4
JournalInternational journal of hematology
Volume82
Issue number3
DOIs
Publication statusPublished - 2005 Oct 1

Keywords

  • Allogeneic stem cell transplantation
  • Autoantibody
  • Autoimmune blistering disease
  • Cicatricial pemphigoid
  • Graft-versus-host disease

ASJC Scopus subject areas

  • Hematology

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