Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

Marisol Cano, Rajesh Thimmalappula, Masashi Fujihara, Norihiro Nagai, Michael Sporn, Ai Ling Wang, Arthur H. Neufeld, Shyam Biswal, James T. Handa

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response.

Original languageEnglish
Pages (from-to)652-664
Number of pages13
JournalVision Research
Volume50
Issue number7
DOIs
Publication statusPublished - 2010 Mar
Externally publishedYes

Fingerprint

Macular Degeneration
Oxidants
Oxidative Stress
Smoking
Epidemiologic Factors
Blindness
Transcription Factors
Epithelium
Therapeutics

Keywords

  • Age-related Macular Degeneration
  • Cigarette smoking
  • Nrf2
  • Oxidative stress
  • Retinal pigmented epithelium

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration. / Cano, Marisol; Thimmalappula, Rajesh; Fujihara, Masashi; Nagai, Norihiro; Sporn, Michael; Wang, Ai Ling; Neufeld, Arthur H.; Biswal, Shyam; Handa, James T.

In: Vision Research, Vol. 50, No. 7, 03.2010, p. 652-664.

Research output: Contribution to journalArticle

Cano, M, Thimmalappula, R, Fujihara, M, Nagai, N, Sporn, M, Wang, AL, Neufeld, AH, Biswal, S & Handa, JT 2010, 'Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration', Vision Research, vol. 50, no. 7, pp. 652-664. https://doi.org/10.1016/j.visres.2009.08.018
Cano, Marisol ; Thimmalappula, Rajesh ; Fujihara, Masashi ; Nagai, Norihiro ; Sporn, Michael ; Wang, Ai Ling ; Neufeld, Arthur H. ; Biswal, Shyam ; Handa, James T. / Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration. In: Vision Research. 2010 ; Vol. 50, No. 7. pp. 652-664.
@article{19d5fd70d00f421b83b0f35cc05b4186,
title = "Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration",
abstract = "Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response.",
keywords = "Age-related Macular Degeneration, Cigarette smoking, Nrf2, Oxidative stress, Retinal pigmented epithelium",
author = "Marisol Cano and Rajesh Thimmalappula and Masashi Fujihara and Norihiro Nagai and Michael Sporn and Wang, {Ai Ling} and Neufeld, {Arthur H.} and Shyam Biswal and Handa, {James T.}",
year = "2010",
month = "3",
doi = "10.1016/j.visres.2009.08.018",
language = "English",
volume = "50",
pages = "652--664",
journal = "Vision Research",
issn = "0042-6989",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

AU - Cano, Marisol

AU - Thimmalappula, Rajesh

AU - Fujihara, Masashi

AU - Nagai, Norihiro

AU - Sporn, Michael

AU - Wang, Ai Ling

AU - Neufeld, Arthur H.

AU - Biswal, Shyam

AU - Handa, James T.

PY - 2010/3

Y1 - 2010/3

N2 - Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response.

AB - Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response.

KW - Age-related Macular Degeneration

KW - Cigarette smoking

KW - Nrf2

KW - Oxidative stress

KW - Retinal pigmented epithelium

UR - http://www.scopus.com/inward/record.url?scp=77950519283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950519283&partnerID=8YFLogxK

U2 - 10.1016/j.visres.2009.08.018

DO - 10.1016/j.visres.2009.08.018

M3 - Article

C2 - 19703486

AN - SCOPUS:77950519283

VL - 50

SP - 652

EP - 664

JO - Vision Research

JF - Vision Research

SN - 0042-6989

IS - 7

ER -