Ciliated muconodular papillary tumors of the lung: A clinicopathologic analysis of 10 cases

Tsugumasa Kamata, Akihiko Yoshida, Tomoo Kosuge, Shun Ichi Watanabe, Hisao Asamura, Koji Tsuta

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Ciliated muconodular papillary tumors (CMPTs) are rare peripheral nodules of the lung first described in 2002. Because of their rarity and nonstandardized diagnostic terminology, CMPTs have been poorly recognized among pathologists. To better characterize these lesions, we undertook a detailed clinicopathologic and immunohistochemical study of 10 archival cases. Ten CMPTs occurred in 7 men and 3 women with a median age of 62 years. All were small peripheral nonendobronchial nodules with a mean diameter of 1.0 cm. All but 1 tumor were incidentally detected by computed tomography-based screening, all of which were radiologically interpreted as adenocarcinomas. Although limited surgery treated all but 1 CMPT, they followed a benign course with no recurrence at a mean follow-up of 43 months (range: 2 to 88 mo). Histologically, CMPTs showed glandular and/or papillary architecture, comprising a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, often enveloped by copious intra-alveolar mucin. Micropapillary tufts of ciliated cells and seemingly discontinuous growth along alveolar walls were occasionally present, mimicking adenocarcinomas. Ciliated cells and basal cells were immunopositive for TTF-1 and p40, respectively, whereas mucous cells lacked HNF4α; expression. CMPTs are rare, likely benign, underrecognized processes of the lung that should be distinguished from adenocarcinomas.

Original languageEnglish
Pages (from-to)753-760
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume39
Issue number6
DOIs
Publication statusPublished - 2015 May 26

Fingerprint

Lung
Neoplasms
Adenocarcinoma
Mucins
Terminology
Tomography
Recurrence
Growth

Keywords

  • diagnosis
  • lung
  • mucus
  • tumor

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

Cite this

Ciliated muconodular papillary tumors of the lung : A clinicopathologic analysis of 10 cases. / Kamata, Tsugumasa; Yoshida, Akihiko; Kosuge, Tomoo; Watanabe, Shun Ichi; Asamura, Hisao; Tsuta, Koji.

In: American Journal of Surgical Pathology, Vol. 39, No. 6, 26.05.2015, p. 753-760.

Research output: Contribution to journalArticle

Kamata, Tsugumasa ; Yoshida, Akihiko ; Kosuge, Tomoo ; Watanabe, Shun Ichi ; Asamura, Hisao ; Tsuta, Koji. / Ciliated muconodular papillary tumors of the lung : A clinicopathologic analysis of 10 cases. In: American Journal of Surgical Pathology. 2015 ; Vol. 39, No. 6. pp. 753-760.
@article{df52d925c0514ca18e59643de489af45,
title = "Ciliated muconodular papillary tumors of the lung: A clinicopathologic analysis of 10 cases",
abstract = "Ciliated muconodular papillary tumors (CMPTs) are rare peripheral nodules of the lung first described in 2002. Because of their rarity and nonstandardized diagnostic terminology, CMPTs have been poorly recognized among pathologists. To better characterize these lesions, we undertook a detailed clinicopathologic and immunohistochemical study of 10 archival cases. Ten CMPTs occurred in 7 men and 3 women with a median age of 62 years. All were small peripheral nonendobronchial nodules with a mean diameter of 1.0 cm. All but 1 tumor were incidentally detected by computed tomography-based screening, all of which were radiologically interpreted as adenocarcinomas. Although limited surgery treated all but 1 CMPT, they followed a benign course with no recurrence at a mean follow-up of 43 months (range: 2 to 88 mo). Histologically, CMPTs showed glandular and/or papillary architecture, comprising a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, often enveloped by copious intra-alveolar mucin. Micropapillary tufts of ciliated cells and seemingly discontinuous growth along alveolar walls were occasionally present, mimicking adenocarcinomas. Ciliated cells and basal cells were immunopositive for TTF-1 and p40, respectively, whereas mucous cells lacked HNF4α; expression. CMPTs are rare, likely benign, underrecognized processes of the lung that should be distinguished from adenocarcinomas.",
keywords = "diagnosis, lung, mucus, tumor",
author = "Tsugumasa Kamata and Akihiko Yoshida and Tomoo Kosuge and Watanabe, {Shun Ichi} and Hisao Asamura and Koji Tsuta",
year = "2015",
month = "5",
day = "26",
doi = "10.1097/PAS.0000000000000414",
language = "English",
volume = "39",
pages = "753--760",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Ciliated muconodular papillary tumors of the lung

T2 - A clinicopathologic analysis of 10 cases

AU - Kamata, Tsugumasa

AU - Yoshida, Akihiko

AU - Kosuge, Tomoo

AU - Watanabe, Shun Ichi

AU - Asamura, Hisao

AU - Tsuta, Koji

PY - 2015/5/26

Y1 - 2015/5/26

N2 - Ciliated muconodular papillary tumors (CMPTs) are rare peripheral nodules of the lung first described in 2002. Because of their rarity and nonstandardized diagnostic terminology, CMPTs have been poorly recognized among pathologists. To better characterize these lesions, we undertook a detailed clinicopathologic and immunohistochemical study of 10 archival cases. Ten CMPTs occurred in 7 men and 3 women with a median age of 62 years. All were small peripheral nonendobronchial nodules with a mean diameter of 1.0 cm. All but 1 tumor were incidentally detected by computed tomography-based screening, all of which were radiologically interpreted as adenocarcinomas. Although limited surgery treated all but 1 CMPT, they followed a benign course with no recurrence at a mean follow-up of 43 months (range: 2 to 88 mo). Histologically, CMPTs showed glandular and/or papillary architecture, comprising a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, often enveloped by copious intra-alveolar mucin. Micropapillary tufts of ciliated cells and seemingly discontinuous growth along alveolar walls were occasionally present, mimicking adenocarcinomas. Ciliated cells and basal cells were immunopositive for TTF-1 and p40, respectively, whereas mucous cells lacked HNF4α; expression. CMPTs are rare, likely benign, underrecognized processes of the lung that should be distinguished from adenocarcinomas.

AB - Ciliated muconodular papillary tumors (CMPTs) are rare peripheral nodules of the lung first described in 2002. Because of their rarity and nonstandardized diagnostic terminology, CMPTs have been poorly recognized among pathologists. To better characterize these lesions, we undertook a detailed clinicopathologic and immunohistochemical study of 10 archival cases. Ten CMPTs occurred in 7 men and 3 women with a median age of 62 years. All were small peripheral nonendobronchial nodules with a mean diameter of 1.0 cm. All but 1 tumor were incidentally detected by computed tomography-based screening, all of which were radiologically interpreted as adenocarcinomas. Although limited surgery treated all but 1 CMPT, they followed a benign course with no recurrence at a mean follow-up of 43 months (range: 2 to 88 mo). Histologically, CMPTs showed glandular and/or papillary architecture, comprising a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, often enveloped by copious intra-alveolar mucin. Micropapillary tufts of ciliated cells and seemingly discontinuous growth along alveolar walls were occasionally present, mimicking adenocarcinomas. Ciliated cells and basal cells were immunopositive for TTF-1 and p40, respectively, whereas mucous cells lacked HNF4α; expression. CMPTs are rare, likely benign, underrecognized processes of the lung that should be distinguished from adenocarcinomas.

KW - diagnosis

KW - lung

KW - mucus

KW - tumor

UR - http://www.scopus.com/inward/record.url?scp=84929905720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929905720&partnerID=8YFLogxK

U2 - 10.1097/PAS.0000000000000414

DO - 10.1097/PAS.0000000000000414

M3 - Article

C2 - 25803171

AN - SCOPUS:84929905720

VL - 39

SP - 753

EP - 760

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 6

ER -