Circadian pattern of fibrillatory events in non-Brugada-type idiopathic ventricular fibrillation with a focus on J waves

Yoshiyasu Aizawa, Masahito Sato, Seiko Ohno, Minoru Horie, Seiji Takatsuki, Keiichi Fukuda, Masaomi Chinushi, Tatsuya Usui, Kazutaka Aonuma, Yukio Hosaka, Michel Haissaguerre, Yoshifusa Aizawa

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15 Citations (Scopus)

Abstract

Background The circadian pattern of ventricular fibrillation (VF) episodes in patients with idiopathic ventricular fibrillation (IVF) is poorly understood.

Methods Excluding Brugada syndrome and other primary electrical diseases, the circadian pattern of VF occurrence was determined in 64 patients with IVF. The clinical and electrocardiographic characteristics were compared among patients with nocturnal (midnight to 6:00 AM) VF and nonnocturnal VF in relation to J waves. A J wave was defined as either notching or a slur at the QRS terminal >0.1 mV above the isoelectric line in contiguous leads.

Results The overall distribution pattern of VF occurrence showed 2 peaks at approximately 6:00 AM and around 8:00 PM. Nocturnal VF was observed in 20 patients (31.3%), and J waves were present in 14 of these 20 individuals (70.0%), whereas J waves were less frequent in the 44 nonnocturnal patients with VF: 16 (36.4%) (P =.0117). Among patients with J waves, nocturnal VF was observed in 46.7% with a peak at approximately 4:00 AM. Nocturnal VF was less common in patients without J waves, occurring in only 17.6% (P =.0124). Both the type and location of J waves and the pattern of the ST segment were similar between the nocturnal and nonnocturnal VF groups. J waves were associated with a VF storm and long-term arrhythmia recurrence.

Conclusion In IVF, the presence of J waves may characterize a higher nocturnal incidence of VF and a higher acute and chronic risk of recurrence.

Original languageEnglish
Pages (from-to)2261-2266
Number of pages6
JournalHeart Rhythm
Volume11
Issue number12
DOIs
Publication statusPublished - 2014 Dec 1

Keywords

  • Circadian rhythm
  • Idiopathic ventricular fibrillation
  • J waves
  • Sudden cardiac death
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Aizawa, Y., Sato, M., Ohno, S., Horie, M., Takatsuki, S., Fukuda, K., Chinushi, M., Usui, T., Aonuma, K., Hosaka, Y., Haissaguerre, M., & Aizawa, Y. (2014). Circadian pattern of fibrillatory events in non-Brugada-type idiopathic ventricular fibrillation with a focus on J waves. Heart Rhythm, 11(12), 2261-2266. https://doi.org/10.1016/j.hrthm.2014.08.022