TY - JOUR
T1 - Circadian regulation of energy intake in mammals
AU - Hirayama, Masatoshi
AU - Mure, Ludovic S.
AU - Panda, Satchidananda
N1 - Funding Information:
This work was supported by U.S. Department of Defense grant W81XWH1810645 , NIH grant DK115214 , EY016807 , and Department of Homeland Security grant EMW-2016-FP-00788 to S.P.; M.H. received support from Glenn Center for Aging Research and JSPS Overseas Research Fellowships . L.M. was partially supported by Fyssen and Catharina foundations .
Publisher Copyright:
© 2018
PY - 2018/10
Y1 - 2018/10
N2 - Optimal integration of central neural circuit regulating hunger-satiety and peripheral metabolic organs involved in nutrient metabolism is necessary for body weight regulation and metabolic homeostasis. Circadian rhythms play an important role in this integrative physiology of metabolism. At the cellular level, the hypothalamic suprachiasmatic nucleus functions as the master circadian oscillator and interacts with peripheral tissues to drive daily rhythm in activity–rest, sleep–wake, and associated rhythms in feeding–fasting. This leads to synchronization and coordination of circadian clocks in peripheral tissues. Several peripheral organs produce neural, hormonal and metabolic signals that convey the overall energy status of the organism to the hypothalamic nuclei regulating hunger and satiety. Circadian rhythms in the expression and function of key genes in both peripheral organs and hypothalamic energy sensing nuclei produce a temporally interactive regulatory mechanism for body weight regulation. Understanding this regulatory mechanism is poised to open new therapeutic avenues to combat obesity and metabolic diseases. In this review, we provide an overview of the neurobiological evidence linking circadian system and food intake regulation and update our understanding of these regulatory pathways from our latest gene expression dataset from a primate.
AB - Optimal integration of central neural circuit regulating hunger-satiety and peripheral metabolic organs involved in nutrient metabolism is necessary for body weight regulation and metabolic homeostasis. Circadian rhythms play an important role in this integrative physiology of metabolism. At the cellular level, the hypothalamic suprachiasmatic nucleus functions as the master circadian oscillator and interacts with peripheral tissues to drive daily rhythm in activity–rest, sleep–wake, and associated rhythms in feeding–fasting. This leads to synchronization and coordination of circadian clocks in peripheral tissues. Several peripheral organs produce neural, hormonal and metabolic signals that convey the overall energy status of the organism to the hypothalamic nuclei regulating hunger and satiety. Circadian rhythms in the expression and function of key genes in both peripheral organs and hypothalamic energy sensing nuclei produce a temporally interactive regulatory mechanism for body weight regulation. Understanding this regulatory mechanism is poised to open new therapeutic avenues to combat obesity and metabolic diseases. In this review, we provide an overview of the neurobiological evidence linking circadian system and food intake regulation and update our understanding of these regulatory pathways from our latest gene expression dataset from a primate.
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U2 - 10.1016/j.cophys.2018.11.002
DO - 10.1016/j.cophys.2018.11.002
M3 - Review article
AN - SCOPUS:85056839917
SN - 2468-8681
VL - 5
SP - 141
EP - 148
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
ER -
