Circulating antibodies to the surface antigens on colon epithelial cells in ulcerative colitis

T. Hibi, S. Aiso, M. Ishikawa, M. Watanabe, T. Yoshida, K. Kobayashi, H. Asakura, S. Tsuru, M. Tsuchiya

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Abstract

The fluorescence activated cell sorter (FACS) was used for detecting circulating antibodies to the surface antigens on isolated colon epithelial cells (anti-colon antibodies) by indirect immunofluorescence. Anti-colon antibodies were found in the serum of 30 of 41 (73%) patients with ulcerative colitis. This incidence is much higher than one established in earlier reports by application of indirect immunofluorescence to colon tissue using the fluorescence microscope. The results suggest that FACS analysis is very useful for detecting antibodies to colon specific antigen.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalClinical and Experimental Immunology
Volume54
Issue number1
Publication statusPublished - 1983 Nov 4

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Hibi, T., Aiso, S., Ishikawa, M., Watanabe, M., Yoshida, T., Kobayashi, K., Asakura, H., Tsuru, S., & Tsuchiya, M. (1983). Circulating antibodies to the surface antigens on colon epithelial cells in ulcerative colitis. Clinical and Experimental Immunology, 54(1), 163-168.