Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, White, and Japanese American middle-aged men

Akira Sekikawa, Takashi Kadowaki, J. David Curb, Rhobert W. Evans, Hiroshi Maegawa, Robert D. Abbott, Kim Sutton-Tyrrell, Tomonori Okamura, Chol Shin, Daniel Edmundowicz, Aya Kadota, Jina Choo, Aiman El-Saed, Hirotsugu Ueshima, Lewis H. Kuller

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study examines the differences in circulating levels of cytokines among Japanese in Japan (JJ), Japanese Americans (JA), and whites and their associations with obesity and marine n-3 fatty acids (FA) in a cross-sectional population-based study of 297 men aged 40-49 (100 JJ, 99 whites, and 98 JA). Experimental studies show that cytokines are associated with obesity positively and marine n-3 FA inversely. Serum interleukin-1α (IL-1α), IL-1 receptor agonist (IL-1ra), IL-4, IL-8, IL-10, inducible protein-10 (IP-10), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and marine n-3 FA were determined. Body mass index (BMI), waist circumference, and computed tomography-measured visceral and subcutaneous adipose tissues were determined. The JJ had significantly lower levels of IL-1α, IL-4, IL-8, MCP-1, and TNF-α than whites and JA. Whites and JA had similar levels of IL-1α, IL-4, and IL-8 whereas whites had significantly higher levels of MCP-1 and TNF-α than JA. The JJ were least obese (BMI (kg/m2), mean-standard deviation) 23.6-2.8, 27.9-4.6, and 27.9-4.5 for JJ, whites, and JA, respectively. The JJ had marine n-3 FA about 100% higher than whites and JA (serum marine n-3 FA (%), median (interquartile range) 8.79 (7.41, 11.16), 3.47 (2.63, 4.83), and 4.44 (3.33, 6.01) for JJ, whites, and JA, respectively). Generally cytokines had weak and nonsignificant associations with indices of obesity and nonsignificant associations with marine n-3 FA. BMI had significant inverse associations with IL-1α, IL-4, and IL-8 in JA (P?<?0.05). Marine n-3 FA had marginally significant inverse associations with IL-8 in JJ (P?=?0.055) and TNF-α in whites (P?=?0.076). The JJ had lower levels of many cytokines than whites and JA. Generally cytokines had weak and nonsignificant associations with indices of obesity and marine n-3 FA. Further investigation is needed to determine why JJ had lower circulating levels of cytokines.

Original languageEnglish
Pages (from-to)541-548
Number of pages8
JournalJournal of Interferon and Cytokine Research
Volume30
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1
Externally publishedYes

Fingerprint

Asian Americans
Omega-3 Fatty Acids
Japan
Obesity
Cytokines
Interleukin-8
Interleukin-1
Interleukin-4
Chemokine CCL2
Tumor Necrosis Factor-alpha
Body Mass Index
Interleukin-1 Receptors
Intra-Abdominal Fat
Subcutaneous Fat
Waist Circumference
Serum
Interleukin-10
Tomography

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Cell Biology

Cite this

Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, White, and Japanese American middle-aged men. / Sekikawa, Akira; Kadowaki, Takashi; Curb, J. David; Evans, Rhobert W.; Maegawa, Hiroshi; Abbott, Robert D.; Sutton-Tyrrell, Kim; Okamura, Tomonori; Shin, Chol; Edmundowicz, Daniel; Kadota, Aya; Choo, Jina; El-Saed, Aiman; Ueshima, Hirotsugu; Kuller, Lewis H.

In: Journal of Interferon and Cytokine Research, Vol. 30, No. 7, 01.07.2010, p. 541-548.

Research output: Contribution to journalArticle

Sekikawa, A, Kadowaki, T, Curb, JD, Evans, RW, Maegawa, H, Abbott, RD, Sutton-Tyrrell, K, Okamura, T, Shin, C, Edmundowicz, D, Kadota, A, Choo, J, El-Saed, A, Ueshima, H & Kuller, LH 2010, 'Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, White, and Japanese American middle-aged men', Journal of Interferon and Cytokine Research, vol. 30, no. 7, pp. 541-548. https://doi.org/10.1089/jir.2009.0114
Sekikawa, Akira ; Kadowaki, Takashi ; Curb, J. David ; Evans, Rhobert W. ; Maegawa, Hiroshi ; Abbott, Robert D. ; Sutton-Tyrrell, Kim ; Okamura, Tomonori ; Shin, Chol ; Edmundowicz, Daniel ; Kadota, Aya ; Choo, Jina ; El-Saed, Aiman ; Ueshima, Hirotsugu ; Kuller, Lewis H. / Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, White, and Japanese American middle-aged men. In: Journal of Interferon and Cytokine Research. 2010 ; Vol. 30, No. 7. pp. 541-548.
@article{28ffcd505fec423bb16936cdff715ef1,
title = "Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, White, and Japanese American middle-aged men",
abstract = "This study examines the differences in circulating levels of cytokines among Japanese in Japan (JJ), Japanese Americans (JA), and whites and their associations with obesity and marine n-3 fatty acids (FA) in a cross-sectional population-based study of 297 men aged 40-49 (100 JJ, 99 whites, and 98 JA). Experimental studies show that cytokines are associated with obesity positively and marine n-3 FA inversely. Serum interleukin-1α (IL-1α), IL-1 receptor agonist (IL-1ra), IL-4, IL-8, IL-10, inducible protein-10 (IP-10), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and marine n-3 FA were determined. Body mass index (BMI), waist circumference, and computed tomography-measured visceral and subcutaneous adipose tissues were determined. The JJ had significantly lower levels of IL-1α, IL-4, IL-8, MCP-1, and TNF-α than whites and JA. Whites and JA had similar levels of IL-1α, IL-4, and IL-8 whereas whites had significantly higher levels of MCP-1 and TNF-α than JA. The JJ were least obese (BMI (kg/m2), mean-standard deviation) 23.6-2.8, 27.9-4.6, and 27.9-4.5 for JJ, whites, and JA, respectively. The JJ had marine n-3 FA about 100{\%} higher than whites and JA (serum marine n-3 FA ({\%}), median (interquartile range) 8.79 (7.41, 11.16), 3.47 (2.63, 4.83), and 4.44 (3.33, 6.01) for JJ, whites, and JA, respectively). Generally cytokines had weak and nonsignificant associations with indices of obesity and nonsignificant associations with marine n-3 FA. BMI had significant inverse associations with IL-1α, IL-4, and IL-8 in JA (P?<?0.05). Marine n-3 FA had marginally significant inverse associations with IL-8 in JJ (P?=?0.055) and TNF-α in whites (P?=?0.076). The JJ had lower levels of many cytokines than whites and JA. Generally cytokines had weak and nonsignificant associations with indices of obesity and marine n-3 FA. Further investigation is needed to determine why JJ had lower circulating levels of cytokines.",
author = "Akira Sekikawa and Takashi Kadowaki and Curb, {J. David} and Evans, {Rhobert W.} and Hiroshi Maegawa and Abbott, {Robert D.} and Kim Sutton-Tyrrell and Tomonori Okamura and Chol Shin and Daniel Edmundowicz and Aya Kadota and Jina Choo and Aiman El-Saed and Hirotsugu Ueshima and Kuller, {Lewis H.}",
year = "2010",
month = "7",
day = "1",
doi = "10.1089/jir.2009.0114",
language = "English",
volume = "30",
pages = "541--548",
journal = "Journal of Interferon and Cytokine Research",
issn = "1079-9907",
publisher = "Mary Ann Liebert Inc.",
number = "7",

}

TY - JOUR

T1 - Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, White, and Japanese American middle-aged men

AU - Sekikawa, Akira

AU - Kadowaki, Takashi

AU - Curb, J. David

AU - Evans, Rhobert W.

AU - Maegawa, Hiroshi

AU - Abbott, Robert D.

AU - Sutton-Tyrrell, Kim

AU - Okamura, Tomonori

AU - Shin, Chol

AU - Edmundowicz, Daniel

AU - Kadota, Aya

AU - Choo, Jina

AU - El-Saed, Aiman

AU - Ueshima, Hirotsugu

AU - Kuller, Lewis H.

PY - 2010/7/1

Y1 - 2010/7/1

N2 - This study examines the differences in circulating levels of cytokines among Japanese in Japan (JJ), Japanese Americans (JA), and whites and their associations with obesity and marine n-3 fatty acids (FA) in a cross-sectional population-based study of 297 men aged 40-49 (100 JJ, 99 whites, and 98 JA). Experimental studies show that cytokines are associated with obesity positively and marine n-3 FA inversely. Serum interleukin-1α (IL-1α), IL-1 receptor agonist (IL-1ra), IL-4, IL-8, IL-10, inducible protein-10 (IP-10), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and marine n-3 FA were determined. Body mass index (BMI), waist circumference, and computed tomography-measured visceral and subcutaneous adipose tissues were determined. The JJ had significantly lower levels of IL-1α, IL-4, IL-8, MCP-1, and TNF-α than whites and JA. Whites and JA had similar levels of IL-1α, IL-4, and IL-8 whereas whites had significantly higher levels of MCP-1 and TNF-α than JA. The JJ were least obese (BMI (kg/m2), mean-standard deviation) 23.6-2.8, 27.9-4.6, and 27.9-4.5 for JJ, whites, and JA, respectively. The JJ had marine n-3 FA about 100% higher than whites and JA (serum marine n-3 FA (%), median (interquartile range) 8.79 (7.41, 11.16), 3.47 (2.63, 4.83), and 4.44 (3.33, 6.01) for JJ, whites, and JA, respectively). Generally cytokines had weak and nonsignificant associations with indices of obesity and nonsignificant associations with marine n-3 FA. BMI had significant inverse associations with IL-1α, IL-4, and IL-8 in JA (P?<?0.05). Marine n-3 FA had marginally significant inverse associations with IL-8 in JJ (P?=?0.055) and TNF-α in whites (P?=?0.076). The JJ had lower levels of many cytokines than whites and JA. Generally cytokines had weak and nonsignificant associations with indices of obesity and marine n-3 FA. Further investigation is needed to determine why JJ had lower circulating levels of cytokines.

AB - This study examines the differences in circulating levels of cytokines among Japanese in Japan (JJ), Japanese Americans (JA), and whites and their associations with obesity and marine n-3 fatty acids (FA) in a cross-sectional population-based study of 297 men aged 40-49 (100 JJ, 99 whites, and 98 JA). Experimental studies show that cytokines are associated with obesity positively and marine n-3 FA inversely. Serum interleukin-1α (IL-1α), IL-1 receptor agonist (IL-1ra), IL-4, IL-8, IL-10, inducible protein-10 (IP-10), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and marine n-3 FA were determined. Body mass index (BMI), waist circumference, and computed tomography-measured visceral and subcutaneous adipose tissues were determined. The JJ had significantly lower levels of IL-1α, IL-4, IL-8, MCP-1, and TNF-α than whites and JA. Whites and JA had similar levels of IL-1α, IL-4, and IL-8 whereas whites had significantly higher levels of MCP-1 and TNF-α than JA. The JJ were least obese (BMI (kg/m2), mean-standard deviation) 23.6-2.8, 27.9-4.6, and 27.9-4.5 for JJ, whites, and JA, respectively. The JJ had marine n-3 FA about 100% higher than whites and JA (serum marine n-3 FA (%), median (interquartile range) 8.79 (7.41, 11.16), 3.47 (2.63, 4.83), and 4.44 (3.33, 6.01) for JJ, whites, and JA, respectively). Generally cytokines had weak and nonsignificant associations with indices of obesity and nonsignificant associations with marine n-3 FA. BMI had significant inverse associations with IL-1α, IL-4, and IL-8 in JA (P?<?0.05). Marine n-3 FA had marginally significant inverse associations with IL-8 in JJ (P?=?0.055) and TNF-α in whites (P?=?0.076). The JJ had lower levels of many cytokines than whites and JA. Generally cytokines had weak and nonsignificant associations with indices of obesity and marine n-3 FA. Further investigation is needed to determine why JJ had lower circulating levels of cytokines.

UR - http://www.scopus.com/inward/record.url?scp=77954905414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954905414&partnerID=8YFLogxK

U2 - 10.1089/jir.2009.0114

DO - 10.1089/jir.2009.0114

M3 - Article

VL - 30

SP - 541

EP - 548

JO - Journal of Interferon and Cytokine Research

JF - Journal of Interferon and Cytokine Research

SN - 1079-9907

IS - 7

ER -