Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome

K. Michizono, F. Umehara, T. Hashiguchi, K. Arimura, E. Matsuura, O. Watanabe, N. Fujimoto, Y. Okada, M. Osame

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The authors quantitatively measured levels of matrix metalloproteinases (MMP), tissue inhibitor of metalloproteinases (TIMP), and vascular endothelial growth factor (VEGF) in blood samples of POEMS syndrome. Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 were more increased in patients with POEMS syndrome than in patients with other neurologic disorders or in healthy controls. Serum levels of VEGF and TIMP-1 were strongly correlated with each other. Increased circulating levels of MMP-1, -2, -3, -9, and TIMP-1 may lead to a better understanding the pathogenesis of POEMS syndrome.

Original languageEnglish
Pages (from-to)807-810
Number of pages4
JournalNeurology
Volume56
Issue number6
Publication statusPublished - 2001 Mar 27

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POEMS Syndrome
Matrix Metalloproteinase 1
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinase 2
Vascular Endothelial Growth Factor A
Tissue Inhibitor of Metalloproteinases
Matrix Metalloproteinase Inhibitors
Nervous System Diseases
Serum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Michizono, K., Umehara, F., Hashiguchi, T., Arimura, K., Matsuura, E., Watanabe, O., ... Osame, M. (2001). Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome. Neurology, 56(6), 807-810.

Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome. / Michizono, K.; Umehara, F.; Hashiguchi, T.; Arimura, K.; Matsuura, E.; Watanabe, O.; Fujimoto, N.; Okada, Y.; Osame, M.

In: Neurology, Vol. 56, No. 6, 27.03.2001, p. 807-810.

Research output: Contribution to journalArticle

Michizono, K, Umehara, F, Hashiguchi, T, Arimura, K, Matsuura, E, Watanabe, O, Fujimoto, N, Okada, Y & Osame, M 2001, 'Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome', Neurology, vol. 56, no. 6, pp. 807-810.
Michizono K, Umehara F, Hashiguchi T, Arimura K, Matsuura E, Watanabe O et al. Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome. Neurology. 2001 Mar 27;56(6):807-810.
Michizono, K. ; Umehara, F. ; Hashiguchi, T. ; Arimura, K. ; Matsuura, E. ; Watanabe, O. ; Fujimoto, N. ; Okada, Y. ; Osame, M. / Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome. In: Neurology. 2001 ; Vol. 56, No. 6. pp. 807-810.
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