TY - JOUR
T1 - Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome
AU - Michizono, K.
AU - Umehara, F.
AU - Hashiguchi, T.
AU - Arimura, K.
AU - Matsuura, E.
AU - Watanabe, O.
AU - Fujimoto, N.
AU - Okada, Y.
AU - Osame, M.
PY - 2001/3/27
Y1 - 2001/3/27
N2 - The authors quantitatively measured levels of matrix metalloproteinases (MMP), tissue inhibitor of metalloproteinases (TIMP), and vascular endothelial growth factor (VEGF) in blood samples of POEMS syndrome. Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 were more increased in patients with POEMS syndrome than in patients with other neurologic disorders or in healthy controls. Serum levels of VEGF and TIMP-1 were strongly correlated with each other. Increased circulating levels of MMP-1, -2, -3, -9, and TIMP-1 may lead to a better understanding the pathogenesis of POEMS syndrome.
AB - The authors quantitatively measured levels of matrix metalloproteinases (MMP), tissue inhibitor of metalloproteinases (TIMP), and vascular endothelial growth factor (VEGF) in blood samples of POEMS syndrome. Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 were more increased in patients with POEMS syndrome than in patients with other neurologic disorders or in healthy controls. Serum levels of VEGF and TIMP-1 were strongly correlated with each other. Increased circulating levels of MMP-1, -2, -3, -9, and TIMP-1 may lead to a better understanding the pathogenesis of POEMS syndrome.
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U2 - 10.1212/WNL.56.6.807
DO - 10.1212/WNL.56.6.807
M3 - Article
C2 - 11274326
AN - SCOPUS:0035957277
SN - 0028-3878
VL - 56
SP - 807
EP - 810
JO - Neurology
JF - Neurology
IS - 6
ER -