Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome

K. Michizono, F. Umehara, T. Hashiguchi, K. Arimura, E. Matsuura, O. Watanabe, N. Fujimoto, Y. Okada, M. Osame

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Abstract

The authors quantitatively measured levels of matrix metalloproteinases (MMP), tissue inhibitor of metalloproteinases (TIMP), and vascular endothelial growth factor (VEGF) in blood samples of POEMS syndrome. Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 were more increased in patients with POEMS syndrome than in patients with other neurologic disorders or in healthy controls. Serum levels of VEGF and TIMP-1 were strongly correlated with each other. Increased circulating levels of MMP-1, -2, -3, -9, and TIMP-1 may lead to a better understanding the pathogenesis of POEMS syndrome.

Original languageEnglish
Pages (from-to)807-810
Number of pages4
JournalNeurology
Volume56
Issue number6
DOIs
Publication statusPublished - 2001 Mar 27

ASJC Scopus subject areas

  • Clinical Neurology

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    Michizono, K., Umehara, F., Hashiguchi, T., Arimura, K., Matsuura, E., Watanabe, O., Fujimoto, N., Okada, Y., & Osame, M. (2001). Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome. Neurology, 56(6), 807-810. https://doi.org/10.1212/WNL.56.6.807