Circulating microRNAs and extracellular vesicles as potential cancer biomarkers: a systematic review

Juntaro Matsuzaki, Takahiro Ochiya

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Circulating non-coding RNAs, including microRNAs and long non-coding RNAs, and the protein components of extracellular vesicles are promising biomarkers for the non-invasive detection of cancer at an early stage. This systematic review discusses the increasing number of well-designed cancer biomarker-related studies that have been published worldwide. In many of these studies, high diagnostic accuracy, which is represented as the area under the receiver operating characteristic curve being >0.8, could be achieved using combinations of circulating microRNAs. In addition, similar diagnostic accuracies were reported using long non-coding RNAs or proteins present in extracellular vesicles, although these evidences were based on a limited number of studies.

Original languageEnglish
Pages (from-to)413-420
Number of pages8
JournalInternational Journal of Clinical Oncology
Volume22
Issue number3
DOIs
Publication statusPublished - 2017 Jun 1
Externally publishedYes

Keywords

  • Cancer
  • Extracellular vesicle
  • Liquid biopsy
  • Long non-coding RNA
  • MicroRNA

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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