CISH controls bacterial burden early after infection with Mycobacterium tuberculosis in mice

Berit Carow, Yu Gao, Graciela Terán, Xuexian O. Yang, Chen Dong, Akihiko Yoshimura, Martin E. Rottenberg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

CISH gene has been associated with increased susceptibility to human tuberculosis. We found that cish−/− mice had higher M. tuberculosis load in spleens and lungs up to 2.5 weeks after infection but not later compared to controls. Cish mRNA levels were increased in lungs at early and late time points after M. tuberculosis infection. In relation, the titers of inos and tnf mRNA in lungs were reduced early after infection of cish−/− mice. The transfer of cish−/− and control T cells conferred rag1−/− mice similar protection to infection with M. tuberculosis. Macrophages showed increased cish mRNA levels after M. tuberculosis infection in vitro. However, mycobacterial uptake and growth in cish−/− and control macrophages was similar. Thus, we here show that CISH mediates control of M. tuberculosis in mice early after infection via regulation of innate immune mechanisms.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalTuberculosis
Volume107
DOIs
Publication statusPublished - 2017 Dec 1

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Keywords

  • Cytokine-inducible SRC homology 2 domain gene
  • Cytokines
  • Macrophage
  • Mycobacterium tuberculosis
  • SOCS
  • T cell

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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