Class-specific binding of two aminoacyl-tRNA synthetases to annexin, a Ca2+-and phospholipid-binding protein

Tomohiro Shirakawa, Akio Nakamura, Kazuhiro Kohama, Michito Hirakata, Satoshi Ogihara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Annexins are a family of Ca2+/phospholipid-binding proteins that have diverse functions. To understand the function of annexin in Physarum polycephalum, we searched for its binding proteins. Here we demonstrate the presence of two novel annexin-binding proteins. The homology search of partial amino acid sequences of these two proteins identified them as aminoacyl-tRNA synthetases (ARSs). Furthermore, antibody against aminoacyl-tRNA synthetases cross-reacted with one of two proteins. Our results imply the interaction between intracellular membrane dynamics and protein translation system, and may give a clue to understand the mechanism of some myositis diseases, which have been known to produce autoantibodies against ARSs.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalCell structure and function
Volume29
Issue number5-6
DOIs
Publication statusPublished - 2005 Feb 1

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Keywords

  • Aminoacyl-tRNA synthetase
  • Annexin
  • Myositis
  • Physarum polycephalum

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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