Clear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau disease: Report of a case

Souya Nunobe, Noriyoshi Fukushima, Shinichi Yachida, Kazuaki Shimada, Tomoo Kosuge, Michiie Sakamoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We describe the case of a pancreatic endocrine tumor with marked clear cell changes. The patient, a 56-year-old woman, presented with appetite loss and nausea but no evidence of either von Hippel-Lindau disease, or a family history of the disease. A radiological examination revealed a hypervascular tumor measuring 5.2cm in diameter located in the pancreatic head. The patient underwent a pylorus-preserving pancreatoduodenectomy. The cut surface of the tumor was yellowish and well demarcated. Histologically, the tumor was composed of cuboidal cells with clear cytoplasm, thus forming trabecular and insular nests. Immunohistochemically, the tumor cells were strongly positive for chromogranin. An electron microscopic examination revealed the tumor cells to contain neuroendocrine secretory granules, abundant lipid droplets, and some crystalloid bodies in the cytoplasm. We conclusively diagnosed it to be a pancreatic clear cell endocrine umor. Such tumors not associated with von Hippel-Lindau disease are extremely rare.

Original languageEnglish
Pages (from-to)470-474
Number of pages5
JournalSurgery Today
Volume33
Issue number6
DOIs
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

von Hippel-Lindau Disease
Islets of Langerhans
Neoplasms
Cytoplasm
Chromogranins
Pancreaticoduodenectomy
Endocrine Cells
Pylorus
Secretory Vesicles
Appetite
Nausea
Electrons

Keywords

  • Clear cell
  • Endocrine tumor
  • Immunohistochemistry
  • Ultrastructural examination

ASJC Scopus subject areas

  • Surgery

Cite this

Clear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau disease : Report of a case. / Nunobe, Souya; Fukushima, Noriyoshi; Yachida, Shinichi; Shimada, Kazuaki; Kosuge, Tomoo; Sakamoto, Michiie.

In: Surgery Today, Vol. 33, No. 6, 2003, p. 470-474.

Research output: Contribution to journalArticle

Nunobe, Souya ; Fukushima, Noriyoshi ; Yachida, Shinichi ; Shimada, Kazuaki ; Kosuge, Tomoo ; Sakamoto, Michiie. / Clear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau disease : Report of a case. In: Surgery Today. 2003 ; Vol. 33, No. 6. pp. 470-474.
@article{971e11a7fc444805b5b28637c972c206,
title = "Clear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau disease: Report of a case",
abstract = "We describe the case of a pancreatic endocrine tumor with marked clear cell changes. The patient, a 56-year-old woman, presented with appetite loss and nausea but no evidence of either von Hippel-Lindau disease, or a family history of the disease. A radiological examination revealed a hypervascular tumor measuring 5.2cm in diameter located in the pancreatic head. The patient underwent a pylorus-preserving pancreatoduodenectomy. The cut surface of the tumor was yellowish and well demarcated. Histologically, the tumor was composed of cuboidal cells with clear cytoplasm, thus forming trabecular and insular nests. Immunohistochemically, the tumor cells were strongly positive for chromogranin. An electron microscopic examination revealed the tumor cells to contain neuroendocrine secretory granules, abundant lipid droplets, and some crystalloid bodies in the cytoplasm. We conclusively diagnosed it to be a pancreatic clear cell endocrine umor. Such tumors not associated with von Hippel-Lindau disease are extremely rare.",
keywords = "Clear cell, Endocrine tumor, Immunohistochemistry, Ultrastructural examination",
author = "Souya Nunobe and Noriyoshi Fukushima and Shinichi Yachida and Kazuaki Shimada and Tomoo Kosuge and Michiie Sakamoto",
year = "2003",
doi = "10.1007/s10595-002-2508-x",
language = "English",
volume = "33",
pages = "470--474",
journal = "Surgery Today",
issn = "0941-1291",
publisher = "Springer Japan",
number = "6",

}

TY - JOUR

T1 - Clear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau disease

T2 - Report of a case

AU - Nunobe, Souya

AU - Fukushima, Noriyoshi

AU - Yachida, Shinichi

AU - Shimada, Kazuaki

AU - Kosuge, Tomoo

AU - Sakamoto, Michiie

PY - 2003

Y1 - 2003

N2 - We describe the case of a pancreatic endocrine tumor with marked clear cell changes. The patient, a 56-year-old woman, presented with appetite loss and nausea but no evidence of either von Hippel-Lindau disease, or a family history of the disease. A radiological examination revealed a hypervascular tumor measuring 5.2cm in diameter located in the pancreatic head. The patient underwent a pylorus-preserving pancreatoduodenectomy. The cut surface of the tumor was yellowish and well demarcated. Histologically, the tumor was composed of cuboidal cells with clear cytoplasm, thus forming trabecular and insular nests. Immunohistochemically, the tumor cells were strongly positive for chromogranin. An electron microscopic examination revealed the tumor cells to contain neuroendocrine secretory granules, abundant lipid droplets, and some crystalloid bodies in the cytoplasm. We conclusively diagnosed it to be a pancreatic clear cell endocrine umor. Such tumors not associated with von Hippel-Lindau disease are extremely rare.

AB - We describe the case of a pancreatic endocrine tumor with marked clear cell changes. The patient, a 56-year-old woman, presented with appetite loss and nausea but no evidence of either von Hippel-Lindau disease, or a family history of the disease. A radiological examination revealed a hypervascular tumor measuring 5.2cm in diameter located in the pancreatic head. The patient underwent a pylorus-preserving pancreatoduodenectomy. The cut surface of the tumor was yellowish and well demarcated. Histologically, the tumor was composed of cuboidal cells with clear cytoplasm, thus forming trabecular and insular nests. Immunohistochemically, the tumor cells were strongly positive for chromogranin. An electron microscopic examination revealed the tumor cells to contain neuroendocrine secretory granules, abundant lipid droplets, and some crystalloid bodies in the cytoplasm. We conclusively diagnosed it to be a pancreatic clear cell endocrine umor. Such tumors not associated with von Hippel-Lindau disease are extremely rare.

KW - Clear cell

KW - Endocrine tumor

KW - Immunohistochemistry

KW - Ultrastructural examination

UR - http://www.scopus.com/inward/record.url?scp=0037683364&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037683364&partnerID=8YFLogxK

U2 - 10.1007/s10595-002-2508-x

DO - 10.1007/s10595-002-2508-x

M3 - Article

C2 - 12768377

AN - SCOPUS:0037683364

VL - 33

SP - 470

EP - 474

JO - Surgery Today

JF - Surgery Today

SN - 0941-1291

IS - 6

ER -