Clear cell variant of malignant melanoma of the uterine cervix: A case report and review of the literature

Mitsuko Furuya, Michio Shimizu, Hiroshi Nishihara, Tomoo Ito, Noriaki Sakuragi, Hiroshi Ishikura, Takashi Yoshiki

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. A rare variant of malignant melanoma of the uterine cervix mimicking clear cell carcinoma or clear cell sarcoma is described. Case. A 33-year-old Japanese woman was admitted to the hospital complaining of genital discharge and lower back pain. The stage was FIGO IIB and radical hysterectomy and pelvic lymphadenectomy were done. Pathological examination, immunohistochemical studies of melanin granules, and molecular analysis of the EWS/ATF-1 fusion gene were also done. A diffuse proliferation of amelanotic clear cells was detected in the uterine cervix. Tumor cells were positive for HMB 45, Melan-A (MART-1), and S-100 protein and negative for epithelial markers. The EWS/ATF-1 fusion gene was not detected. Conclusion. This is apparently the first report of a case of clear cell melanoma of the uterine cervix. Despite its rarity, this variant of malignant melanoma should be considered when diagnosing clear cell neoplasms of the uterine cervix.

Original languageEnglish
Pages (from-to)409-412
Number of pages4
JournalGynecologic Oncology
Volume80
Issue number3
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

Fingerprint

Cervix Uteri
Melanoma
Gene Fusion
Clear Cell Sarcoma
MART-1 Antigen
S100 Proteins
Melanins
Low Back Pain
Lymph Node Excision
Hysterectomy
Neoplasms
Carcinoma

Keywords

  • Clear cell
  • Malignant melanoma
  • Uterine cervix

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Clear cell variant of malignant melanoma of the uterine cervix : A case report and review of the literature. / Furuya, Mitsuko; Shimizu, Michio; Nishihara, Hiroshi; Ito, Tomoo; Sakuragi, Noriaki; Ishikura, Hiroshi; Yoshiki, Takashi.

In: Gynecologic Oncology, Vol. 80, No. 3, 01.01.2001, p. 409-412.

Research output: Contribution to journalArticle

Furuya, Mitsuko ; Shimizu, Michio ; Nishihara, Hiroshi ; Ito, Tomoo ; Sakuragi, Noriaki ; Ishikura, Hiroshi ; Yoshiki, Takashi. / Clear cell variant of malignant melanoma of the uterine cervix : A case report and review of the literature. In: Gynecologic Oncology. 2001 ; Vol. 80, No. 3. pp. 409-412.
@article{c3ad6a386e5f4b02bc957b990f27b95e,
title = "Clear cell variant of malignant melanoma of the uterine cervix: A case report and review of the literature",
abstract = "Background. A rare variant of malignant melanoma of the uterine cervix mimicking clear cell carcinoma or clear cell sarcoma is described. Case. A 33-year-old Japanese woman was admitted to the hospital complaining of genital discharge and lower back pain. The stage was FIGO IIB and radical hysterectomy and pelvic lymphadenectomy were done. Pathological examination, immunohistochemical studies of melanin granules, and molecular analysis of the EWS/ATF-1 fusion gene were also done. A diffuse proliferation of amelanotic clear cells was detected in the uterine cervix. Tumor cells were positive for HMB 45, Melan-A (MART-1), and S-100 protein and negative for epithelial markers. The EWS/ATF-1 fusion gene was not detected. Conclusion. This is apparently the first report of a case of clear cell melanoma of the uterine cervix. Despite its rarity, this variant of malignant melanoma should be considered when diagnosing clear cell neoplasms of the uterine cervix.",
keywords = "Clear cell, Malignant melanoma, Uterine cervix",
author = "Mitsuko Furuya and Michio Shimizu and Hiroshi Nishihara and Tomoo Ito and Noriaki Sakuragi and Hiroshi Ishikura and Takashi Yoshiki",
year = "2001",
month = "1",
day = "1",
doi = "10.1006/gyno.2000.6091",
language = "English",
volume = "80",
pages = "409--412",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Clear cell variant of malignant melanoma of the uterine cervix

T2 - A case report and review of the literature

AU - Furuya, Mitsuko

AU - Shimizu, Michio

AU - Nishihara, Hiroshi

AU - Ito, Tomoo

AU - Sakuragi, Noriaki

AU - Ishikura, Hiroshi

AU - Yoshiki, Takashi

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Background. A rare variant of malignant melanoma of the uterine cervix mimicking clear cell carcinoma or clear cell sarcoma is described. Case. A 33-year-old Japanese woman was admitted to the hospital complaining of genital discharge and lower back pain. The stage was FIGO IIB and radical hysterectomy and pelvic lymphadenectomy were done. Pathological examination, immunohistochemical studies of melanin granules, and molecular analysis of the EWS/ATF-1 fusion gene were also done. A diffuse proliferation of amelanotic clear cells was detected in the uterine cervix. Tumor cells were positive for HMB 45, Melan-A (MART-1), and S-100 protein and negative for epithelial markers. The EWS/ATF-1 fusion gene was not detected. Conclusion. This is apparently the first report of a case of clear cell melanoma of the uterine cervix. Despite its rarity, this variant of malignant melanoma should be considered when diagnosing clear cell neoplasms of the uterine cervix.

AB - Background. A rare variant of malignant melanoma of the uterine cervix mimicking clear cell carcinoma or clear cell sarcoma is described. Case. A 33-year-old Japanese woman was admitted to the hospital complaining of genital discharge and lower back pain. The stage was FIGO IIB and radical hysterectomy and pelvic lymphadenectomy were done. Pathological examination, immunohistochemical studies of melanin granules, and molecular analysis of the EWS/ATF-1 fusion gene were also done. A diffuse proliferation of amelanotic clear cells was detected in the uterine cervix. Tumor cells were positive for HMB 45, Melan-A (MART-1), and S-100 protein and negative for epithelial markers. The EWS/ATF-1 fusion gene was not detected. Conclusion. This is apparently the first report of a case of clear cell melanoma of the uterine cervix. Despite its rarity, this variant of malignant melanoma should be considered when diagnosing clear cell neoplasms of the uterine cervix.

KW - Clear cell

KW - Malignant melanoma

KW - Uterine cervix

UR - http://www.scopus.com/inward/record.url?scp=0035097056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035097056&partnerID=8YFLogxK

U2 - 10.1006/gyno.2000.6091

DO - 10.1006/gyno.2000.6091

M3 - Article

C2 - 11263942

AN - SCOPUS:0035097056

VL - 80

SP - 409

EP - 412

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 3

ER -