Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η1-coordination mode

Satoshi Nishino, Mami Kunita, Yoshiyuki Kani, Shigeru Ohba, Hideaki Matsushima, Tadashi Tokii, Yuzo Nishida

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We have obtained clear evidence that a copper(II)-peroxide adduct with an η1-coordination mode can cleave the C-N bond of a peptide group and hydroxylate the alkyl group nearby; this may provide helpful information for elucidation of the reaction mechanism of PAM, peptidylglycine α-amidating monooxygenase. (C) 2000 Elsevier Science S.A.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalInorganic Chemistry Communications
Volume3
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

Pulse amplitude modulation
Peroxides
peroxides
Mixed Function Oxygenases
Peptides
adducts
peptides
Copper
cleavage
pulse amplitude modulation
copper
peptidylglycine monooxygenase

Keywords

  • η-Coordination mode
  • Cleavage of protein
  • Copper(II)-peroxide adduct
  • Model reaction for PAM enzyme

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η1-coordination mode. / Nishino, Satoshi; Kunita, Mami; Kani, Yoshiyuki; Ohba, Shigeru; Matsushima, Hideaki; Tokii, Tadashi; Nishida, Yuzo.

In: Inorganic Chemistry Communications, Vol. 3, No. 3, 2000, p. 145-148.

Research output: Contribution to journalArticle

Nishino, Satoshi ; Kunita, Mami ; Kani, Yoshiyuki ; Ohba, Shigeru ; Matsushima, Hideaki ; Tokii, Tadashi ; Nishida, Yuzo. / Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η1-coordination mode. In: Inorganic Chemistry Communications. 2000 ; Vol. 3, No. 3. pp. 145-148.
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AU - Matsushima, Hideaki

AU - Tokii, Tadashi

AU - Nishida, Yuzo

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