Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η1-coordination mode

Satoshi Nishino, Mami Kunita, Yoshiyuki Kani, Shigeru Ohba, Hideaki Matsushima, Tadashi Tokii, Yuzo Nishida

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

We have obtained clear evidence that a copper(II)-peroxide adduct with an η1-coordination mode can cleave the C-N bond of a peptide group and hydroxylate the alkyl group nearby; this may provide helpful information for elucidation of the reaction mechanism of PAM, peptidylglycine α-amidating monooxygenase. (C) 2000 Elsevier Science S.A.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalInorganic Chemistry Communications
Volume3
Issue number3
DOIs
Publication statusPublished - 2000 Oct 7

Keywords

  • Cleavage of protein
  • Copper(II)-peroxide adduct
  • Model reaction for PAM enzyme
  • η-Coordination mode

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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