Abstract
Novel click chemistry was developed based on the biosynthetic process of firefly luciferin, which includes an ideal coupling of a cyanothiazole residue with cysteine. Among various biomimetic couplings of nitriles with cysteine derivatives, the approach using 4-cyanopyridine and cysteine methyl ester provided a very rapid and quantitative conversion to the corresponding thiazole without any metal catalyst at room temperature.
Original language | English |
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Pages (from-to) | 753-755 |
Number of pages | 3 |
Journal | Chemistry Letters |
Volume | 46 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Biomimetic coupling
- Click chemistry
- Firefly luciferin
ASJC Scopus subject areas
- Chemistry(all)