Clinical and biological correlates of resilience in patients with schizophrenia and bipolar disorder: A cross-sectional study

Yuya Mizuno, Alex Hofer, Takefumi Suzuki, Beatrice Frajo-Apor, Fabienne Wartelsteiner, Georg Kemmler, Juri Saruta, Keiichi Tsukinoki, Masaru Mimura, W. Wolfgang Fleischhacker, Hiroyuki Uchida

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: The concept of resilience is relevant in understanding the heterogeneous outcomes noted in schizophrenia and bipolar disorder. However, clinical and biological correlates of resilience in these populations have rarely been investigated. We aimed to identify key correlates of subjective resilience in such patients using comprehensive assessments and to explore associations between resilience levels and peripheral biomarkers. Method: 180 subjects with DSM-IV schizophrenia, bipolar disorder, and healthy controls (60 per group) were included. Demographic and clinical variables were assessed by means of interview and various psychometric scales. Furthermore, blood and saliva samples were obtained for the assessment of brain-derived neurotrophic factor, adrenocorticotropic hormone, cortisol, high sensitivity C-reactive protein, and alpha-amylase levels. Cross-sectional associations with resilience, as assessed by the 25-item Resilience Scale were sought. Results: Resilience Scale total scores were significantly higher in healthy individuals (130.1, 95% confidence intervals (CI): 124.8-135.4) compared to subjects with schizophrenia (109.9, 95% CI: 104.6-115.2, p.

Original languageEnglish
JournalSchizophrenia Research
DOIs
Publication statusAccepted/In press - 2015 Sep 3

Fingerprint

Bipolar Disorder
Schizophrenia
Cross-Sectional Studies
Confidence Intervals
alpha-Amylases
Brain-Derived Neurotrophic Factor
Saliva
Psychometrics
Diagnostic and Statistical Manual of Mental Disorders
C-Reactive Protein
Adrenocorticotropic Hormone
Hydrocortisone
Biomarkers
Demography
Interviews
Population

Keywords

  • Biomarkers
  • Bipolar disorder
  • Recovery
  • Resilience
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Clinical and biological correlates of resilience in patients with schizophrenia and bipolar disorder : A cross-sectional study. / Mizuno, Yuya; Hofer, Alex; Suzuki, Takefumi; Frajo-Apor, Beatrice; Wartelsteiner, Fabienne; Kemmler, Georg; Saruta, Juri; Tsukinoki, Keiichi; Mimura, Masaru; Fleischhacker, W. Wolfgang; Uchida, Hiroyuki.

In: Schizophrenia Research, 03.09.2015.

Research output: Contribution to journalArticle

Mizuno, Yuya ; Hofer, Alex ; Suzuki, Takefumi ; Frajo-Apor, Beatrice ; Wartelsteiner, Fabienne ; Kemmler, Georg ; Saruta, Juri ; Tsukinoki, Keiichi ; Mimura, Masaru ; Fleischhacker, W. Wolfgang ; Uchida, Hiroyuki. / Clinical and biological correlates of resilience in patients with schizophrenia and bipolar disorder : A cross-sectional study. In: Schizophrenia Research. 2015.
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