TY - JOUR
T1 - Clinical and histological findings associated with autoantibodies detected by RNA immunoprecipitation in inflammatory myopathies
AU - Suzuki, Shigeaki
AU - Yonekawa, Takahiro
AU - Kuwana, Masataka
AU - Hayashi, Yukiko K.
AU - Okazaki, Yuka
AU - Kawaguchi, Yasushi
AU - Suzuki, Norihiro
AU - Nishino, Ichizo
N1 - Funding Information:
We thank all of the physicians who provided muscle biopsy and serum samples and the detailed clinical information. Support was received in the form of a grant from the Japanese Ministry of Education, Science, Sports and Culture (no. 26461298 ); a Health and Labour Sciences Research Grant on Intractable Diseases (Neuroimmunological Diseases) from the Ministry of Health, Labour and Welfare of Japan ; Intramural Research Grants for Neurological and Psychiatric Disorders of NCNP (nos. 23-5 and 23-4 ); Grants for Research on Intractable Diseases and Comprehensive Research on Disability Health and Welfare from the Ministry of Health, Labour and Welfare of Japan ; a Grant-in-Aid for Scientific Research (B) from MEXT (no. 24390227 ), and a Grant-in-Aid for Challenging Exploratory Research ( 24659437 ).
PY - 2014
Y1 - 2014
N2 - Of 207 adult patients with idiopathic inflammatory myopathies, detection of autoantibodies by RNA immunoprecipitation showed that 99 patients (48%) were antibody-positive. We divided these 99 into five subgroups: anti-signal recognition particle (SRP), anti-aminoacyl transfer RNA synthetase, anti-Ku, anti-U1RNP, and anti-SSA/B. Younger age at onset, severe weakness, muscle atrophy, elevated creatine kinase, and necrosis in muscle fibers without inflammatory cell infiltration were found significantly more frequently among the patients with anti-SRP antibodies (n = 41) compared to the antibody-negative patients (n = 108). Autoantibody detection by RNA immunoprecipitation can provide useful information associated with clinical and histological findings.
AB - Of 207 adult patients with idiopathic inflammatory myopathies, detection of autoantibodies by RNA immunoprecipitation showed that 99 patients (48%) were antibody-positive. We divided these 99 into five subgroups: anti-signal recognition particle (SRP), anti-aminoacyl transfer RNA synthetase, anti-Ku, anti-U1RNP, and anti-SSA/B. Younger age at onset, severe weakness, muscle atrophy, elevated creatine kinase, and necrosis in muscle fibers without inflammatory cell infiltration were found significantly more frequently among the patients with anti-SRP antibodies (n = 41) compared to the antibody-negative patients (n = 108). Autoantibody detection by RNA immunoprecipitation can provide useful information associated with clinical and histological findings.
KW - Autoantibodies
KW - Inflammatory myopathies
KW - Muscle biopsy
KW - Necrotizing myopathy
KW - RNA immunoprecipitation
KW - Signal recognition particle
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U2 - 10.1016/j.jneuroim.2014.07.006
DO - 10.1016/j.jneuroim.2014.07.006
M3 - Article
C2 - 25064497
AN - SCOPUS:84906936786
VL - 274
SP - 202
EP - 208
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -