Clinical and histological findings associated with autoantibodies detected by RNA immunoprecipitation in inflammatory myopathies

Shigeaki Suzuki, Takahiro Yonekawa, Masataka Kuwana, Yukiko K. Hayashi, Yuka Okazaki, Yasushi Kawaguchi, Norihiro Suzuki, Ichizo Nishino

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Of 207 adult patients with idiopathic inflammatory myopathies, detection of autoantibodies by RNA immunoprecipitation showed that 99 patients (48%) were antibody-positive. We divided these 99 into five subgroups: anti-signal recognition particle (SRP), anti-aminoacyl transfer RNA synthetase, anti-Ku, anti-U1RNP, and anti-SSA/B. Younger age at onset, severe weakness, muscle atrophy, elevated creatine kinase, and necrosis in muscle fibers without inflammatory cell infiltration were found significantly more frequently among the patients with anti-SRP antibodies (n = 41) compared to the antibody-negative patients (n = 108). Autoantibody detection by RNA immunoprecipitation can provide useful information associated with clinical and histological findings.

Original languageEnglish
Pages (from-to)202-208
Number of pages7
JournalJournal of Neuroimmunology
Volume274
Issue number1-2
DOIs
Publication statusPublished - 2014 Jan 1

Keywords

  • Autoantibodies
  • Inflammatory myopathies
  • Muscle biopsy
  • Necrotizing myopathy
  • RNA immunoprecipitation
  • Signal recognition particle

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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