Clinical and immunological differences between early and late-onset myasthenia gravis in Japan

Shigeaki Suzuki, Kimiaki Utsugisawa, Yuriko Nagane, Takashi Satoh, Masataka Kuwana, Norihiro Suzuki

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Immunological characteristics of myasthenia gravis (MG) with late-onset have not been fully elucidated. We examined several autoantibodies and HLA-DRB1 genotyping in 260 Japanese MG patients. Sixty-two MG patients had thymoma. The others were divided into early-onset and late-onset groups separated by an age of 50. years. The ocular form was more frequent in late-onset compared to early-onset group. Seropositivity of anti-muscle-specific tyrosine kinase antibody was 2-3% in acetylcholine receptor-seronegative patients. HLA-DRB1 genotyping failed to detect statistical differences in specific alleles between each group and healthy controls. The immunological profiles in late-onset MG were different from early-onset in Japan.

Original languageEnglish
Pages (from-to)148-152
Number of pages5
JournalJournal of Neuroimmunology
Volume230
Issue number1-2
DOIs
Publication statusPublished - 2011 Jan

Fingerprint

Myasthenia Gravis
Japan
HLA-DRB1 Chains
Thymoma
Cholinergic Receptors
Autoantibodies
Protein-Tyrosine Kinases
Age Groups
Alleles
Muscles
Control Groups
Antibodies

Keywords

  • Autoantibody
  • HLA
  • Late onset
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Clinical and immunological differences between early and late-onset myasthenia gravis in Japan. / Suzuki, Shigeaki; Utsugisawa, Kimiaki; Nagane, Yuriko; Satoh, Takashi; Kuwana, Masataka; Suzuki, Norihiro.

In: Journal of Neuroimmunology, Vol. 230, No. 1-2, 01.2011, p. 148-152.

Research output: Contribution to journalArticle

Suzuki, Shigeaki ; Utsugisawa, Kimiaki ; Nagane, Yuriko ; Satoh, Takashi ; Kuwana, Masataka ; Suzuki, Norihiro. / Clinical and immunological differences between early and late-onset myasthenia gravis in Japan. In: Journal of Neuroimmunology. 2011 ; Vol. 230, No. 1-2. pp. 148-152.
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