Clinical and immunological differences between early and late-onset myasthenia gravis in Japan

Shigeaki Suzuki, Kimiaki Utsugisawa, Yuriko Nagane, Takashi Satoh, Masataka Kuwana, Norihiro Suzuki

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Immunological characteristics of myasthenia gravis (MG) with late-onset have not been fully elucidated. We examined several autoantibodies and HLA-DRB1 genotyping in 260 Japanese MG patients. Sixty-two MG patients had thymoma. The others were divided into early-onset and late-onset groups separated by an age of 50. years. The ocular form was more frequent in late-onset compared to early-onset group. Seropositivity of anti-muscle-specific tyrosine kinase antibody was 2-3% in acetylcholine receptor-seronegative patients. HLA-DRB1 genotyping failed to detect statistical differences in specific alleles between each group and healthy controls. The immunological profiles in late-onset MG were different from early-onset in Japan.

Original languageEnglish
Pages (from-to)148-152
Number of pages5
JournalJournal of Neuroimmunology
Volume230
Issue number1-2
DOIs
Publication statusPublished - 2011 Jan 1

Keywords

  • Autoantibody
  • HLA
  • Late onset
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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