Clinical and pathological features of B-cell non-Hodgkin lymphomas lacking the surface expression of immunoglobulin light chains

Hiromichi Matsushita, Naoya Nakamura, Yuzo Tanaka, Daisuke Ohgiya, Yumiko Tanaka, Anar Damdinsuren, Satomi Asai, Miharu Yabe, Hiroshi Kawada, Yoshiaki Ogawa, Kiyoshi Ando, Hayato Miyachi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: The flow cytometric analysis of surface immunoglobulin light chains (sIgL) is used as a simple method for evaluating monoclonal B-cell proliferation. However, the sIgL expression, κ or λ, is occasionally undetectable in cases with B-cell non-Hodgkin lymphomas (B-NHL). The purpose of this study was to investigate the clinical and pathological characteristics of these B-NHL cases. Methods: We retrospectively analyzed 50 cases with previously untreated sIgL-negative B-NHL. All of these cases had been diagnosed at Tokai University Hospital between January 2001 and February 2011. Their medical charts were reviewed. Results: These cases had several clinical features: diffuse large B-cell lymphoma (DLBCL) (72 %), a high serum lactate dehydrogenase level (66 %), clinical stage III and IV (68 %), and complex karyotypes (58 %). Seven out of eight evaluated patients (87 %) did not express cytoplasmic IgL, and the DNA rearrangement pattern of IgL showed diversity in 10 analyzed patients. The 5-year event-free survival of all the sIgL-negative B-NHL cases was significantly better with rituximabcontaining chemotherapies in comparison to the regimens without it (57.9 % vs. 17.9 %, p = 0.0207), although there was no statistical significance when the DLBCL cases were analyzed (56.6 % vs. 22.2 %, p = 0.1530). Conclusions: These findings suggest that sIgL-negative B-NHL cases predominantly developed DLBCL in advanced disease, but were heterogeneous at the molecular level.

Original languageEnglish
Pages (from-to)1665-1670
Number of pages6
JournalClinical Chemistry and Laboratory Medicine
Issue number9
Publication statusPublished - 2012 Sept
Externally publishedYes


  • Diffuse large B-cell lymphoma
  • Non-Hodgkin lymphoma
  • Rituximab
  • Southern blotting analysis
  • Surface immunoglobulin light chains

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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