Clinical application of living-related conjunctival-limbal allograft

Kazuo Tsubota, Shigeto Shimmura, Naoshi Shinozaki, Edward J. Holland, Jun Shimazaki

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

PURPOSE: To report one successful case of conjunctival-limbal allograft for the treatment of a severe ocular surface disorder. METHODS: Interventional case report. A 9-year-old patient suffering from Stevens-Johnson syndrome with total keratinization of the ocular surface of both eyes was treated in the left eye by corneal and conjunctival stem cell transplantation. Oral cyclosporin A and topical autologous serum and corticosteroids were administered. RESULTS: Mucosal epithelial phenotype was maintained in the left eye at most recent examination for more than 3 years after ocular surface reconstruction. CONCLUSION: A total keratinized ocular surface may be treated with the combination of conjunctival and corneal stem cell transplantation.

Original languageEnglish
Pages (from-to)134-135
Number of pages2
JournalAmerican Journal of Ophthalmology
Volume133
Issue number1
DOIs
Publication statusPublished - 2002

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Allografts
Stem Cell Transplantation
Stevens-Johnson Syndrome
Cyclosporine
Adrenal Cortex Hormones
Phenotype
Serum

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Clinical application of living-related conjunctival-limbal allograft. / Tsubota, Kazuo; Shimmura, Shigeto; Shinozaki, Naoshi; Holland, Edward J.; Shimazaki, Jun.

In: American Journal of Ophthalmology, Vol. 133, No. 1, 2002, p. 134-135.

Research output: Contribution to journalArticle

Tsubota, Kazuo ; Shimmura, Shigeto ; Shinozaki, Naoshi ; Holland, Edward J. ; Shimazaki, Jun. / Clinical application of living-related conjunctival-limbal allograft. In: American Journal of Ophthalmology. 2002 ; Vol. 133, No. 1. pp. 134-135.
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