Clinical biopsychosocial risk factors for depression in lung cancer patients: A comprehensive analysis using data from the lung cancer database project

K. Shimizu, N. Nakaya, K. Saito-Nakaya, T. Akechi, Y. Yamada, M. Fujimori, A. Ogawa, Daisuke Fujisawa, K. Goto, M. Iwasaki, S. Tsugane, Y. Uchitomi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Various risk factors for depression in lung cancer patients have been suggested but have been examined separately in studies with relatively small sample sizes. The present study examined the biopsychosocial risk factors of depression in lung cancer patients, focusing on psychological factors in the largest patient sample reported to date. Patients and methods: A total of 1334 consecutively recruited lung cancer patients were selected, and data on cancer-related variables, personal characteristics, health behaviors, physical symptoms, and psychological factors were obtained. The participants were divided into groups with or without depression using the Hospital Anxiety and Depression Scale. Results: Among the recruited patients, 165 (12.4%) manifested depression. The results of a binary logistic regression analysis were significant (overall R2, 36.5%), and a greater risk for depression was strongly associated with psychological factors, such as personality characteristics (neuroticism) and coping style (low fighting spirit, helplessness/hopelessness, and anxious preoccupation). Although the contributions of cancer-related variables, personal characteristics, health behaviors, and clinical state were relatively low, cancer stage, cancer type, sex, and age correlated significantly with depression. Conclusion: Depression was most strongly linked with personality traits and coping style, and using screening instruments to identify these factors may be useful for preventive interventions.

Original languageEnglish
Article numbermds061
Pages (from-to)1973-1979
Number of pages7
JournalAnnals of Oncology
Volume23
Issue number8
DOIs
Publication statusPublished - 2012 Aug
Externally publishedYes

Fingerprint

Lung Neoplasms
Databases
Depression
Health Behavior
Psychology
Personality
Neoplasms
Sample Size
Anxiety
Logistic Models
Regression Analysis

Keywords

  • Coping
  • Depression
  • Lung carcinoma
  • Personality
  • Quality of life
  • Supportive care

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Shimizu, K., Nakaya, N., Saito-Nakaya, K., Akechi, T., Yamada, Y., Fujimori, M., ... Uchitomi, Y. (2012). Clinical biopsychosocial risk factors for depression in lung cancer patients: A comprehensive analysis using data from the lung cancer database project. Annals of Oncology, 23(8), 1973-1979. [mds061]. https://doi.org/10.1093/annonc/mds061

Clinical biopsychosocial risk factors for depression in lung cancer patients : A comprehensive analysis using data from the lung cancer database project. / Shimizu, K.; Nakaya, N.; Saito-Nakaya, K.; Akechi, T.; Yamada, Y.; Fujimori, M.; Ogawa, A.; Fujisawa, Daisuke; Goto, K.; Iwasaki, M.; Tsugane, S.; Uchitomi, Y.

In: Annals of Oncology, Vol. 23, No. 8, mds061, 08.2012, p. 1973-1979.

Research output: Contribution to journalArticle

Shimizu, K, Nakaya, N, Saito-Nakaya, K, Akechi, T, Yamada, Y, Fujimori, M, Ogawa, A, Fujisawa, D, Goto, K, Iwasaki, M, Tsugane, S & Uchitomi, Y 2012, 'Clinical biopsychosocial risk factors for depression in lung cancer patients: A comprehensive analysis using data from the lung cancer database project', Annals of Oncology, vol. 23, no. 8, mds061, pp. 1973-1979. https://doi.org/10.1093/annonc/mds061
Shimizu, K. ; Nakaya, N. ; Saito-Nakaya, K. ; Akechi, T. ; Yamada, Y. ; Fujimori, M. ; Ogawa, A. ; Fujisawa, Daisuke ; Goto, K. ; Iwasaki, M. ; Tsugane, S. ; Uchitomi, Y. / Clinical biopsychosocial risk factors for depression in lung cancer patients : A comprehensive analysis using data from the lung cancer database project. In: Annals of Oncology. 2012 ; Vol. 23, No. 8. pp. 1973-1979.
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