Clinical characteristics of Japanese patients with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibodies

Shinji Sato, M. Kuwana, Michito Hirakata

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objectives. The clinical and laboratory characteristics of seven patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies, specifically anti-OJ (anti-isoleucyl-tRNA synthetase), were examined and co pared with previously published findings. Methods. Serum samples from 1135 Japanese patients with various autoimmune diseases and 48 normal individuals were screened for anti-OJ antibodies using RNA and protein immunoprecipitation assays. The patients whose sea contained anti-OJ antibodies were assessed regarding clinical symptoms, clinical course, laboratory findings, chest radiography and chest computed tomography. Results. Sera from seven patients were found to contain anti-OJ antibodies. These autoantibodies were associated with interstitial lung disease (ILD) and myositis. The diagnoses of the seven patients were idiopathic interstitial pneumonias (IIPs) in three, polymyositis (PM) in three and PM-rheumatoid arthritis (RA) overlap in the remaining one. All patients had ILD, but muscle weakness and polyarthritis were seen only in four. Raynaud's phenomenon and sclerodactyly were absent in all patients. Conclusions. These results indicate that the presence of anti-OJ autoantibodies may distinguish a subtype of anti-ARS syndrome that is more closely associated with ILD than myositis or Raynaud's phenomenon.

Original languageEnglish
Pages (from-to)842-845
Number of pages4
JournalRheumatology
Volume46
Issue number5
DOIs
Publication statusPublished - 2007 May

Fingerprint

Isoleucine-tRNA Ligase
Autoantibodies
Interstitial Lung Diseases
Amino Acyl-tRNA Synthetases
Polymyositis
Anti-Idiotypic Antibodies
Raynaud Disease
Myositis
Thorax
Idiopathic Interstitial Pneumonias
Muscle Weakness
Serum
Immunoprecipitation
Radiography
Oceans and Seas
Autoimmune Diseases
Arthritis
Rheumatoid Arthritis
Tomography
RNA

Keywords

  • Anti-aminoacyl-tRNA synthetase (ARS) antibodies
  • Interstitial lung disease (ILD)
  • Polymyositis/dermatomyositis (PM/DM)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Rheumatology

Cite this

Clinical characteristics of Japanese patients with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibodies. / Sato, Shinji; Kuwana, M.; Hirakata, Michito.

In: Rheumatology, Vol. 46, No. 5, 05.2007, p. 842-845.

Research output: Contribution to journalArticle

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