Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies

Shinji Sato, Michito Hirakata, Masataka Kuwana, Kunio Nakamura, Akira Suwa, Shinichi Inada, Tsuneyo Mimori, Yasuo Ikeda

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Abstract

Objective: The clinical and laboratory features of seven Japanese patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies against PL-7 (anti-threonyl-tRNA synthetase) were analyzed and compared with previously published findings. Methods: Serum samples from 1,135 Japanese patients with various autoimmune diseases were screened for anti-PL-7 antibodies using RNA and protein immunoprecipitation assays. The patients whose sera contained anti-PL-7 antibodies were assessed regarding clinical symptoms and clinical course. Results: Sera from seven patients were found to have anti-PL-7 antibodies. These autoantibodies were associated with polymyositis/dermatomyositis (PM/DM) and/or interstitial lung disease (ILD). The clinical diagnoses of these seven patients were PM - systemic sclerosis (SSc) overlap (5 patients), DM (1 patient) and idiopathic pulmonary fibrosis (IPF) (1 patient). All patients had ILD with a chronic course and six also had arthritis (85%) and five sclerodactyly (71%). Conclusions: These results indicate that anti-PL-7 autoantibodies are closely associated with PM-SSc overlap as well as ILD, arthritis and sclerodactyly in our series of Japanese patients.

Original languageEnglish
Pages (from-to)609-615
Number of pages7
JournalClinical and experimental rheumatology
Volume23
Issue number5
Publication statusPublished - 2005 Sep 1

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Keywords

  • Anti-aminoacyl-tRNA synthetases (ARS) antibodies
  • Interstitial lung disease (ILD)
  • Polymyositis/dermatomyositis (PM/DM)

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Sato, S., Hirakata, M., Kuwana, M., Nakamura, K., Suwa, A., Inada, S., Mimori, T., & Ikeda, Y. (2005). Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies. Clinical and experimental rheumatology, 23(5), 609-615.