Clinical characteristics of patients with spondyloarthritis in Japan in comparison with other regions of the world

Mitsumasa Kishimoto, Kazuki Yoshida, Naomi Ichikawa, Hisashi Inoue, Yuko Kaneko, Taku Kawasaki, Kazuo Matsui, Mitsuhiro Morita, Masei Suda, Kurisu Tada, Naoho Takizawa, Naoto Tamura, Atsuo Taniguchi, Yoshinori Taniguchi, Shigeyoshi Tsuji, Yoichiro Haji, Ryo Rokutanda, Haruyuki Yanaoka, Peter P. Cheung, Jieruo GuTae Hwan Kim, Shue Fen Luo, Masato Okada, Clementina López Medina, Anna Molto, Maxime Dougados, Shigeto Kobayashi, Désirée Van Der Heijde, Tetsuya Tomita

Research output: Contribution to journalArticle

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Abstract

Objective. To delineate clinical characteristics of patients with spondyloarthritis (SpA) in Japan in comparison to other areas of the world. Methods. Using the ASAS-COMOSPA (Assessment of Spondyloarthritis international Society–COMOrbidities in SPondyloArthritis) data, an international cross-sectional observational study of patients with SpA, we analyzed information on demographics, disease characteristics, comorbidities, and risk factors. Patients were classified by region: Japan, other Asian countries (China, Singapore, South Korea, Taiwan), and non-Asian countries (Europe, the Americas, Africa). Patient characteristics, including diagnosis and treatment, were compared. Results. Among 3984 patients included in the study, 161 were from centers in Japan, 933 from other Asian countries, and 2890 from other regions. Of patients with SpA in Japan, 42 (26.1%) had peripheral SpA, substantially more than in other countries. This trend was explained by the predominance of psoriatic arthritis (PsA) among Japanese patients with SpA. In contrast to the relatively low number in Japan, 54% of patients from other Asian countries had pure axial SpA (axSpA) without peripheral features. HLA-B27 testing, considered an integral part of the classification of axSpA, was performed in only 63.6% of Japanese patients with axSpA. More than half of Japanese patients with axSpA were classified using imaging criteria. Conclusion. In our study, there was a more substantial number of peripheral SpA cases observed in Japan compared to other parts of Asia and other regions of the world. Aside from ethnic differences, increasing recognition of PsA in Japan, as well as a potential underdiagnosis of axSpA due to the insufficient use of HLA-B27 testing, may partly explain regional discrepancies.

Original languageEnglish
Pages (from-to)896-903
Number of pages8
JournalJournal of Rheumatology
Volume46
Issue number8
DOIs
Publication statusPublished - 2019 Aug 1

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Japan
HLA-B27 Antigen
Psoriatic Arthritis
Republic of Korea
Singapore
Taiwan
Observational Studies
Comorbidity
China
Cross-Sectional Studies
Demography

Keywords

  • Ankylosing spondylitis
  • Axial spondyloarthritis
  • Classification criteria
  • Peripheral spondyloarthritis
  • Psoriatic arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Clinical characteristics of patients with spondyloarthritis in Japan in comparison with other regions of the world. / Kishimoto, Mitsumasa; Yoshida, Kazuki; Ichikawa, Naomi; Inoue, Hisashi; Kaneko, Yuko; Kawasaki, Taku; Matsui, Kazuo; Morita, Mitsuhiro; Suda, Masei; Tada, Kurisu; Takizawa, Naoho; Tamura, Naoto; Taniguchi, Atsuo; Taniguchi, Yoshinori; Tsuji, Shigeyoshi; Haji, Yoichiro; Rokutanda, Ryo; Yanaoka, Haruyuki; Cheung, Peter P.; Gu, Jieruo; Kim, Tae Hwan; Luo, Shue Fen; Okada, Masato; Medina, Clementina López; Molto, Anna; Dougados, Maxime; Kobayashi, Shigeto; Van Der Heijde, Désirée; Tomita, Tetsuya.

In: Journal of Rheumatology, Vol. 46, No. 8, 01.08.2019, p. 896-903.

Research output: Contribution to journalArticle

Kishimoto, M, Yoshida, K, Ichikawa, N, Inoue, H, Kaneko, Y, Kawasaki, T, Matsui, K, Morita, M, Suda, M, Tada, K, Takizawa, N, Tamura, N, Taniguchi, A, Taniguchi, Y, Tsuji, S, Haji, Y, Rokutanda, R, Yanaoka, H, Cheung, PP, Gu, J, Kim, TH, Luo, SF, Okada, M, Medina, CL, Molto, A, Dougados, M, Kobayashi, S, Van Der Heijde, D & Tomita, T 2019, 'Clinical characteristics of patients with spondyloarthritis in Japan in comparison with other regions of the world', Journal of Rheumatology, vol. 46, no. 8, pp. 896-903. https://doi.org/10.3899/jrheum.180412
Kishimoto, Mitsumasa ; Yoshida, Kazuki ; Ichikawa, Naomi ; Inoue, Hisashi ; Kaneko, Yuko ; Kawasaki, Taku ; Matsui, Kazuo ; Morita, Mitsuhiro ; Suda, Masei ; Tada, Kurisu ; Takizawa, Naoho ; Tamura, Naoto ; Taniguchi, Atsuo ; Taniguchi, Yoshinori ; Tsuji, Shigeyoshi ; Haji, Yoichiro ; Rokutanda, Ryo ; Yanaoka, Haruyuki ; Cheung, Peter P. ; Gu, Jieruo ; Kim, Tae Hwan ; Luo, Shue Fen ; Okada, Masato ; Medina, Clementina López ; Molto, Anna ; Dougados, Maxime ; Kobayashi, Shigeto ; Van Der Heijde, Désirée ; Tomita, Tetsuya. / Clinical characteristics of patients with spondyloarthritis in Japan in comparison with other regions of the world. In: Journal of Rheumatology. 2019 ; Vol. 46, No. 8. pp. 896-903.
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abstract = "Objective. To delineate clinical characteristics of patients with spondyloarthritis (SpA) in Japan in comparison to other areas of the world. Methods. Using the ASAS-COMOSPA (Assessment of Spondyloarthritis international Society–COMOrbidities in SPondyloArthritis) data, an international cross-sectional observational study of patients with SpA, we analyzed information on demographics, disease characteristics, comorbidities, and risk factors. Patients were classified by region: Japan, other Asian countries (China, Singapore, South Korea, Taiwan), and non-Asian countries (Europe, the Americas, Africa). Patient characteristics, including diagnosis and treatment, were compared. Results. Among 3984 patients included in the study, 161 were from centers in Japan, 933 from other Asian countries, and 2890 from other regions. Of patients with SpA in Japan, 42 (26.1{\%}) had peripheral SpA, substantially more than in other countries. This trend was explained by the predominance of psoriatic arthritis (PsA) among Japanese patients with SpA. In contrast to the relatively low number in Japan, 54{\%} of patients from other Asian countries had pure axial SpA (axSpA) without peripheral features. HLA-B27 testing, considered an integral part of the classification of axSpA, was performed in only 63.6{\%} of Japanese patients with axSpA. More than half of Japanese patients with axSpA were classified using imaging criteria. Conclusion. In our study, there was a more substantial number of peripheral SpA cases observed in Japan compared to other parts of Asia and other regions of the world. Aside from ethnic differences, increasing recognition of PsA in Japan, as well as a potential underdiagnosis of axSpA due to the insufficient use of HLA-B27 testing, may partly explain regional discrepancies.",
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T1 - Clinical characteristics of patients with spondyloarthritis in Japan in comparison with other regions of the world

AU - Kishimoto, Mitsumasa

AU - Yoshida, Kazuki

AU - Ichikawa, Naomi

AU - Inoue, Hisashi

AU - Kaneko, Yuko

AU - Kawasaki, Taku

AU - Matsui, Kazuo

AU - Morita, Mitsuhiro

AU - Suda, Masei

AU - Tada, Kurisu

AU - Takizawa, Naoho

AU - Tamura, Naoto

AU - Taniguchi, Atsuo

AU - Taniguchi, Yoshinori

AU - Tsuji, Shigeyoshi

AU - Haji, Yoichiro

AU - Rokutanda, Ryo

AU - Yanaoka, Haruyuki

AU - Cheung, Peter P.

AU - Gu, Jieruo

AU - Kim, Tae Hwan

AU - Luo, Shue Fen

AU - Okada, Masato

AU - Medina, Clementina López

AU - Molto, Anna

AU - Dougados, Maxime

AU - Kobayashi, Shigeto

AU - Van Der Heijde, Désirée

AU - Tomita, Tetsuya

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Objective. To delineate clinical characteristics of patients with spondyloarthritis (SpA) in Japan in comparison to other areas of the world. Methods. Using the ASAS-COMOSPA (Assessment of Spondyloarthritis international Society–COMOrbidities in SPondyloArthritis) data, an international cross-sectional observational study of patients with SpA, we analyzed information on demographics, disease characteristics, comorbidities, and risk factors. Patients were classified by region: Japan, other Asian countries (China, Singapore, South Korea, Taiwan), and non-Asian countries (Europe, the Americas, Africa). Patient characteristics, including diagnosis and treatment, were compared. Results. Among 3984 patients included in the study, 161 were from centers in Japan, 933 from other Asian countries, and 2890 from other regions. Of patients with SpA in Japan, 42 (26.1%) had peripheral SpA, substantially more than in other countries. This trend was explained by the predominance of psoriatic arthritis (PsA) among Japanese patients with SpA. In contrast to the relatively low number in Japan, 54% of patients from other Asian countries had pure axial SpA (axSpA) without peripheral features. HLA-B27 testing, considered an integral part of the classification of axSpA, was performed in only 63.6% of Japanese patients with axSpA. More than half of Japanese patients with axSpA were classified using imaging criteria. Conclusion. In our study, there was a more substantial number of peripheral SpA cases observed in Japan compared to other parts of Asia and other regions of the world. Aside from ethnic differences, increasing recognition of PsA in Japan, as well as a potential underdiagnosis of axSpA due to the insufficient use of HLA-B27 testing, may partly explain regional discrepancies.

AB - Objective. To delineate clinical characteristics of patients with spondyloarthritis (SpA) in Japan in comparison to other areas of the world. Methods. Using the ASAS-COMOSPA (Assessment of Spondyloarthritis international Society–COMOrbidities in SPondyloArthritis) data, an international cross-sectional observational study of patients with SpA, we analyzed information on demographics, disease characteristics, comorbidities, and risk factors. Patients were classified by region: Japan, other Asian countries (China, Singapore, South Korea, Taiwan), and non-Asian countries (Europe, the Americas, Africa). Patient characteristics, including diagnosis and treatment, were compared. Results. Among 3984 patients included in the study, 161 were from centers in Japan, 933 from other Asian countries, and 2890 from other regions. Of patients with SpA in Japan, 42 (26.1%) had peripheral SpA, substantially more than in other countries. This trend was explained by the predominance of psoriatic arthritis (PsA) among Japanese patients with SpA. In contrast to the relatively low number in Japan, 54% of patients from other Asian countries had pure axial SpA (axSpA) without peripheral features. HLA-B27 testing, considered an integral part of the classification of axSpA, was performed in only 63.6% of Japanese patients with axSpA. More than half of Japanese patients with axSpA were classified using imaging criteria. Conclusion. In our study, there was a more substantial number of peripheral SpA cases observed in Japan compared to other parts of Asia and other regions of the world. Aside from ethnic differences, increasing recognition of PsA in Japan, as well as a potential underdiagnosis of axSpA due to the insufficient use of HLA-B27 testing, may partly explain regional discrepancies.

KW - Ankylosing spondylitis

KW - Axial spondyloarthritis

KW - Classification criteria

KW - Peripheral spondyloarthritis

KW - Psoriatic arthritis

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