TY - JOUR
T1 - Clinical characteristics of pediatric febrile urinary tract infection in Japan
AU - Ohnishi, Takuma
AU - Mishima, Yoshinori
AU - Matsuda, Nozomi
AU - Sato, Daisuke
AU - Umino, Daisuke
AU - Yonezawa, Ryuta
AU - Kinoshita, Keiji
AU - Tamura, Kikuko
AU - Mimura, Shigenao
AU - Ariji, Shohei
AU - Maeda, Naonori
AU - Ozaki, Keiko
AU - Fukushima, Hiroyuki
AU - Arakuma, Tomohiro
AU - Tsuchida, Satoko
AU - Nishimoto, Hajime
AU - Araki, Yoshinori
AU - Yoshida, Makoto
AU - Tamame, Takuya
AU - Suzuki, Shigeru
AU - Sekijima, Toshio
AU - Kowase, Takanori
AU - Takahashi, Kanae
AU - Kamimaki, Isamu
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2021/3
Y1 - 2021/3
N2 - Background: Febrile urinary tract infection (fUTI) is the most common serious bacterial infection in children. Despite this, there have been no studies examining the clinical features of pediatric fUTI in Japan. The purpose of this study was to describe the clinical characteristics of fUTI in Japanese children. Methods: A multicenter, retrospective, observational study was conducted at 21 hospitals in Japan. Children under the age of 15 years who were diagnosed with fUTI between 2008 and 2017 were included. The diagnostic criteria were a temperature over 38 °C and the presence of a single bacterial pathogen in urine culture. Patient characteristics were obtained from medical records. Results: In total, 2,049 children were included in the study. The median age was 5 months, and 59.3% were male. It was found that 87.0% of the males and 53.2% of the females were under 1 year of age. The main causative pathogens identified were Escherichia coli and Enterococcus spp., accounting for 76.6% and 9.8% of infections, respectively. Conclusions: There was a male predominance of fUTI in Japanese children, particularly in infants. Enterococcus spp. were the second most frequent causative pathogen; therefore, Gram staining of urine samples is strongly recommended before initiating antibiotic therapy.
AB - Background: Febrile urinary tract infection (fUTI) is the most common serious bacterial infection in children. Despite this, there have been no studies examining the clinical features of pediatric fUTI in Japan. The purpose of this study was to describe the clinical characteristics of fUTI in Japanese children. Methods: A multicenter, retrospective, observational study was conducted at 21 hospitals in Japan. Children under the age of 15 years who were diagnosed with fUTI between 2008 and 2017 were included. The diagnostic criteria were a temperature over 38 °C and the presence of a single bacterial pathogen in urine culture. Patient characteristics were obtained from medical records. Results: In total, 2,049 children were included in the study. The median age was 5 months, and 59.3% were male. It was found that 87.0% of the males and 53.2% of the females were under 1 year of age. The main causative pathogens identified were Escherichia coli and Enterococcus spp., accounting for 76.6% and 9.8% of infections, respectively. Conclusions: There was a male predominance of fUTI in Japanese children, particularly in infants. Enterococcus spp. were the second most frequent causative pathogen; therefore, Gram staining of urine samples is strongly recommended before initiating antibiotic therapy.
KW - Enterococcus
KW - Hydronephrosis
KW - Urinary tract infection
KW - Vesicoureteral reflux
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U2 - 10.1016/j.ijid.2020.12.066
DO - 10.1016/j.ijid.2020.12.066
M3 - Article
C2 - 33383218
AN - SCOPUS:85099616851
SN - 1201-9712
VL - 104
SP - 97
EP - 101
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
