Clinical characteristics of pulmonary Mycobacterium lentiflavum disease in adult patients

Kazuma Yagi, Kozo Morimoto, Makoto Ishii, Ho Namkoong, Satoshi Okamori, Takanori Asakura, Shoji Suzuki, Takahiro Asami, Yoshifumi Uwamino, Yohei Funatsu, Hiroshi Fujiwara, Hirofumi Kamata, Tomoyasu Nishimura, Tomoko Betsuyaku, Atsuyuki Kurashima, Naoki Hasegawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background Mycobacterium lentiflavum is a slow-growing non-tuberculous Mycobacterium that is often associated with an immunocompromised state and cervical lymphadenitis in young children. However, little is known about the clinical importance of pulmonary infection with M. lentiflavum in adults. Methods The medical records of all adults who met the diagnostic criteria of pulmonary M. lentiflavum disease at Keio University Hospital and Fukujuji Hospital from 2001 to 2015 were reviewed. In addition, the PubMed database was searched to identify further reported cases in non-HIV adults. Results Five cases of pulmonary M. lentiflavum disease were identified in the medical records search and 11 additional cases were identified in the literature review. Eleven of the total 16 cases were female, and 15 of 16 cases showed a nodular/bronchiectatic pattern on chest computed tomography imaging. No cases showed an aggressive clinical course of pulmonary M. lentiflavum disease, although one patient died of an exacerbation of underlying vasculitis and bacterial pneumonia. Conclusions The clinical characteristics of pulmonary M. lentiflavum disease in adult patients were identified. This disease mainly affects females, displays a nodular/bronchiectatic pattern on chest computed tomography imaging, and does not demonstrate an aggressive clinical course. Further larger studies are needed to reveal detailed clinical features.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalInternational Journal of Infectious Diseases
Volume67
DOIs
Publication statusPublished - 2018 Feb 1

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Mycobacterium
Lung
Medical Records
Thorax
Tomography
Bacterial Pneumonia
Lymphadenitis
Vasculitis
PubMed
Databases
Infection

Keywords

  • Case series
  • Literature review
  • Non-tuberculous mycobacteria
  • Pulmonary Mycobacterium lentiflavum disease

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Clinical characteristics of pulmonary Mycobacterium lentiflavum disease in adult patients. / Yagi, Kazuma; Morimoto, Kozo; Ishii, Makoto; Namkoong, Ho; Okamori, Satoshi; Asakura, Takanori; Suzuki, Shoji; Asami, Takahiro; Uwamino, Yoshifumi; Funatsu, Yohei; Fujiwara, Hiroshi; Kamata, Hirofumi; Nishimura, Tomoyasu; Betsuyaku, Tomoko; Kurashima, Atsuyuki; Hasegawa, Naoki.

In: International Journal of Infectious Diseases, Vol. 67, 01.02.2018, p. 65-69.

Research output: Contribution to journalArticle

Yagi, Kazuma ; Morimoto, Kozo ; Ishii, Makoto ; Namkoong, Ho ; Okamori, Satoshi ; Asakura, Takanori ; Suzuki, Shoji ; Asami, Takahiro ; Uwamino, Yoshifumi ; Funatsu, Yohei ; Fujiwara, Hiroshi ; Kamata, Hirofumi ; Nishimura, Tomoyasu ; Betsuyaku, Tomoko ; Kurashima, Atsuyuki ; Hasegawa, Naoki. / Clinical characteristics of pulmonary Mycobacterium lentiflavum disease in adult patients. In: International Journal of Infectious Diseases. 2018 ; Vol. 67. pp. 65-69.
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