Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012

Hirotaka Ohara, Kazuichi Okazaki, Hirohito Tsubouchi, Kazuo Inui, Shigeyuki Kawa, Terumi Kamisawa, Susumu Tazuma, Kazushige Uchida, Kenji Hirano, Hitoshi Yoshida, Takayoshi Nishino, Shigeru Ko, Nobumasa Mizuno, Hideaki Hamano, Atsushi Kanno, Kenji Notohara, Osamu Hasebe, Takahiro Nakazawa, Yasuni Nakanuma, Hajime Takikawa

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Background: IgG4-sclerosing cholangitis (IgG4-SC) patients have an increased level of serum IgG4, dense infiltration of IgG4-positive plasma cells with extensive fibrosis in the bile duct wall, and a good response to steroid therapy. However, it is not easy to distinguish IgG4-SC from primary sclerosing cholangitis, pancreatic cancer, and cholangiocarcinoma on the basis of cholangiographic findings alone because various cholangiographic features of IgG4-SC are similar to those of the above progressive or malignant diseases. Methods: The Research Committee of IgG4-related Diseases and the Research Committee of Intractable Diseases of Liver and Biliary Tract in association with the Ministry of Health, Labor and Welfare, Japan and the Japan Biliary Association have set up a working group consisting of researchers specializing in IgG4-SC, and established the new clinical diagnostic criteria of IgG4-SC 2012. Results: The diagnosis of IgG4-SC is based on the combination of the following 4 criteria: (1) characteristic biliary imaging findings, (2) elevation of serum IgG4 concentrations, (3) the coexistence of IgG4-related diseases except those of the biliary tract, and (4) characteristic histopathological features. Furthermore, the effectiveness of steroid therapy is an optional extra diagnostic criterion to confirm accurate diagnosis of IgG4-SC. Conclusion: These diagnostic criteria for IgG4-SC are useful in practice for general physicians and other nonspecialists.

Original languageEnglish
Pages (from-to)536-542
Number of pages7
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume19
Issue number5
DOIs
Publication statusPublished - 2012 Sep
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Immunoglobulin G
Japan
Steroids
Biliary Tract Diseases
Cholangiocarcinoma
Biliary Tract
Plasma Cells
Bile Ducts
Serum
Pancreatic Neoplasms
Research
General Practitioners

Keywords

  • Autoimmune pancreatitis
  • Cholangiocarcinoma
  • IgG4
  • Primary sclerosing cholangitis
  • Sclerosing cholangitis

ASJC Scopus subject areas

  • Hepatology
  • Surgery

Cite this

Ohara, H., Okazaki, K., Tsubouchi, H., Inui, K., Kawa, S., Kamisawa, T., ... Takikawa, H. (2012). Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012. Journal of Hepato-Biliary-Pancreatic Sciences, 19(5), 536-542. https://doi.org/10.1007/s00534-012-0521-y

Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012. / Ohara, Hirotaka; Okazaki, Kazuichi; Tsubouchi, Hirohito; Inui, Kazuo; Kawa, Shigeyuki; Kamisawa, Terumi; Tazuma, Susumu; Uchida, Kazushige; Hirano, Kenji; Yoshida, Hitoshi; Nishino, Takayoshi; Ko, Shigeru; Mizuno, Nobumasa; Hamano, Hideaki; Kanno, Atsushi; Notohara, Kenji; Hasebe, Osamu; Nakazawa, Takahiro; Nakanuma, Yasuni; Takikawa, Hajime.

In: Journal of Hepato-Biliary-Pancreatic Sciences, Vol. 19, No. 5, 09.2012, p. 536-542.

Research output: Contribution to journalArticle

Ohara, H, Okazaki, K, Tsubouchi, H, Inui, K, Kawa, S, Kamisawa, T, Tazuma, S, Uchida, K, Hirano, K, Yoshida, H, Nishino, T, Ko, S, Mizuno, N, Hamano, H, Kanno, A, Notohara, K, Hasebe, O, Nakazawa, T, Nakanuma, Y & Takikawa, H 2012, 'Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012', Journal of Hepato-Biliary-Pancreatic Sciences, vol. 19, no. 5, pp. 536-542. https://doi.org/10.1007/s00534-012-0521-y
Ohara, Hirotaka ; Okazaki, Kazuichi ; Tsubouchi, Hirohito ; Inui, Kazuo ; Kawa, Shigeyuki ; Kamisawa, Terumi ; Tazuma, Susumu ; Uchida, Kazushige ; Hirano, Kenji ; Yoshida, Hitoshi ; Nishino, Takayoshi ; Ko, Shigeru ; Mizuno, Nobumasa ; Hamano, Hideaki ; Kanno, Atsushi ; Notohara, Kenji ; Hasebe, Osamu ; Nakazawa, Takahiro ; Nakanuma, Yasuni ; Takikawa, Hajime. / Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012. In: Journal of Hepato-Biliary-Pancreatic Sciences. 2012 ; Vol. 19, No. 5. pp. 536-542.
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abstract = "Background: IgG4-sclerosing cholangitis (IgG4-SC) patients have an increased level of serum IgG4, dense infiltration of IgG4-positive plasma cells with extensive fibrosis in the bile duct wall, and a good response to steroid therapy. However, it is not easy to distinguish IgG4-SC from primary sclerosing cholangitis, pancreatic cancer, and cholangiocarcinoma on the basis of cholangiographic findings alone because various cholangiographic features of IgG4-SC are similar to those of the above progressive or malignant diseases. Methods: The Research Committee of IgG4-related Diseases and the Research Committee of Intractable Diseases of Liver and Biliary Tract in association with the Ministry of Health, Labor and Welfare, Japan and the Japan Biliary Association have set up a working group consisting of researchers specializing in IgG4-SC, and established the new clinical diagnostic criteria of IgG4-SC 2012. Results: The diagnosis of IgG4-SC is based on the combination of the following 4 criteria: (1) characteristic biliary imaging findings, (2) elevation of serum IgG4 concentrations, (3) the coexistence of IgG4-related diseases except those of the biliary tract, and (4) characteristic histopathological features. Furthermore, the effectiveness of steroid therapy is an optional extra diagnostic criterion to confirm accurate diagnosis of IgG4-SC. Conclusion: These diagnostic criteria for IgG4-SC are useful in practice for general physicians and other nonspecialists.",
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T1 - Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012

AU - Ohara, Hirotaka

AU - Okazaki, Kazuichi

AU - Tsubouchi, Hirohito

AU - Inui, Kazuo

AU - Kawa, Shigeyuki

AU - Kamisawa, Terumi

AU - Tazuma, Susumu

AU - Uchida, Kazushige

AU - Hirano, Kenji

AU - Yoshida, Hitoshi

AU - Nishino, Takayoshi

AU - Ko, Shigeru

AU - Mizuno, Nobumasa

AU - Hamano, Hideaki

AU - Kanno, Atsushi

AU - Notohara, Kenji

AU - Hasebe, Osamu

AU - Nakazawa, Takahiro

AU - Nakanuma, Yasuni

AU - Takikawa, Hajime

PY - 2012/9

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N2 - Background: IgG4-sclerosing cholangitis (IgG4-SC) patients have an increased level of serum IgG4, dense infiltration of IgG4-positive plasma cells with extensive fibrosis in the bile duct wall, and a good response to steroid therapy. However, it is not easy to distinguish IgG4-SC from primary sclerosing cholangitis, pancreatic cancer, and cholangiocarcinoma on the basis of cholangiographic findings alone because various cholangiographic features of IgG4-SC are similar to those of the above progressive or malignant diseases. Methods: The Research Committee of IgG4-related Diseases and the Research Committee of Intractable Diseases of Liver and Biliary Tract in association with the Ministry of Health, Labor and Welfare, Japan and the Japan Biliary Association have set up a working group consisting of researchers specializing in IgG4-SC, and established the new clinical diagnostic criteria of IgG4-SC 2012. Results: The diagnosis of IgG4-SC is based on the combination of the following 4 criteria: (1) characteristic biliary imaging findings, (2) elevation of serum IgG4 concentrations, (3) the coexistence of IgG4-related diseases except those of the biliary tract, and (4) characteristic histopathological features. Furthermore, the effectiveness of steroid therapy is an optional extra diagnostic criterion to confirm accurate diagnosis of IgG4-SC. Conclusion: These diagnostic criteria for IgG4-SC are useful in practice for general physicians and other nonspecialists.

AB - Background: IgG4-sclerosing cholangitis (IgG4-SC) patients have an increased level of serum IgG4, dense infiltration of IgG4-positive plasma cells with extensive fibrosis in the bile duct wall, and a good response to steroid therapy. However, it is not easy to distinguish IgG4-SC from primary sclerosing cholangitis, pancreatic cancer, and cholangiocarcinoma on the basis of cholangiographic findings alone because various cholangiographic features of IgG4-SC are similar to those of the above progressive or malignant diseases. Methods: The Research Committee of IgG4-related Diseases and the Research Committee of Intractable Diseases of Liver and Biliary Tract in association with the Ministry of Health, Labor and Welfare, Japan and the Japan Biliary Association have set up a working group consisting of researchers specializing in IgG4-SC, and established the new clinical diagnostic criteria of IgG4-SC 2012. Results: The diagnosis of IgG4-SC is based on the combination of the following 4 criteria: (1) characteristic biliary imaging findings, (2) elevation of serum IgG4 concentrations, (3) the coexistence of IgG4-related diseases except those of the biliary tract, and (4) characteristic histopathological features. Furthermore, the effectiveness of steroid therapy is an optional extra diagnostic criterion to confirm accurate diagnosis of IgG4-SC. Conclusion: These diagnostic criteria for IgG4-SC are useful in practice for general physicians and other nonspecialists.

KW - Autoimmune pancreatitis

KW - Cholangiocarcinoma

KW - IgG4

KW - Primary sclerosing cholangitis

KW - Sclerosing cholangitis

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