Clinical efficacy and safety of intravenous itraconazole in the management of invasive candidiasis in patients ofsurgery and critical care

Yoshio Takesue, Shigeto Oda, Seitaro Fujishima, Hiroshige Mikamo, Naoki Aikawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Although itraconazole exhibits potent activity against Candida species, there have been few studies examining the use ofintravenous itraconazole in the treatment of invasive candidiasis. A nationwide multicenter clinical study was conducted toevaluate the efficacy and safety of intravenous itraconazole in the management of invasive candidiasis, includingnon-albicans Candida species, in non-neutropenic patients undergoing surgery and critical care. Between September 2007 andAugust 2009, patients with proven and presumed candidiasis were enrolled at 22 participating institutions. Patients withpresumed candidiasis had a deep-body temperature of 37.8°C or higher and were positive for serum β-d-glucan or twoor more colonization sites of Candida species. The main exclusion criterion was severe renal impairment (creatinine clearance<30 ml/min). The primary efficacy analysis was based on clinical and microbiological responses 5-10 days after the end oftreatment, assessed by an independent data review committee. Of the 60 patients enrolled, 49 were included in the modifiedintention-to-treat population; 31 patients received a definitive diagnosis and 18 patients a presumed diagnosis. Intravenousitraconazole was used as first-line therapy to treat 39 patients and as second-line therapy for 10 patients. The isolatedspecies included Candida albicans (25 strains with definitive diagnosis and 17 with presumed diagnosis) and non-albicansspecies (16 and 10, respectively). Treatment was successful in 61.5% patients (65.5% in first-line and 50.0% in second-linetherapy); 60% of proven invasive candidiasis (IC) patients were judged as successful compared with 63.2% of presumedcandidiasis patients. Eradication rate was 63.6% for C. albicans and 71.4% for C. glabrata. Adverse effects occurred in 9 of60 patients (15.0%), commonly impaired liver function. The clinical efficacy and safety of intravenous itraconazole weresuggested in the management of proven and presumed candidiasis including C. glabrata in non-neutropenic patients. The statusof intravenous itraconazole in the Japanese guideline warrants reconsideration.

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalJournal of Infection and Chemotherapy
Volume18
Issue number4
DOIs
Publication statusPublished - 2012 Aug

Keywords

  • Candida glabrata
  • Critical care
  • Intravenous itraconazole
  • Invasive candidiasis
  • Surgery

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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