Clinical factors related to the aqueous levels of vascular endothelial growth factor and hepatocyte growth factor in proliferative diabetic retinopathy

K. Shinoda, S. Ishida, S. Kawashima, T. Wakabayashi, M. Uchita, T. Matsuzaki, Michiyo Takayama, K. Shinmura, M. Yamada

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Purpose. To investigate clinical factors related to the aqueous humor levels of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with proliferative diabetic retinopathy (PDR). Methods. Undiluted aqueous humor was obtained during ocular surgery from 46 eyes of 46 patients and the levels of growth factors were measured using enzyme-linked immunosorbent assays. VEGF and HGF levels were compared with the number of photocoagulation. VEGF and HGF levels in patient groups stratified according to the existence of vitreous hemorrhage, retinal detachment, and fibrovascular membrane were analyzed. And clinical parameters associated with the growth factors were determined by multiple regression analysis. Results. The levels of VEGF decreased significantly as the extent of photocoagulation increased and showed significant positive correlation with the existence of vitreous hemorrhage. There was no significant correlation between VEGF levels and the existence of fibrovascular membrane and traction retinal detachment. The levels of HGF also decreased significantly as the extent of photocoagulation increased, but increased significantly when fibrovascular membrane existed. There were no significant correlations between HGF levels and the existence of vitreous hemorrhage and traction retinal detachment. Concerning systemic conditions, each growth factor has no significant correlation with duration and type of diabetes mellitus, the treatment regimen, the control of hemoglobin A1C, and the existences of hypertension or renal dysfunction. Conclusion. The therapeutic effect of panretinal photocoagulation on PDR might be partly exerted by reduction of the levels of VEGF and HGF in ocular fluid. Since the clinical parameters associated with VEGF were different from those associated with HGF, these growth factors might influence the progression of retinopathy in different ways.

Original languageEnglish
Pages (from-to)655-661
Number of pages7
JournalCurrent Eye Research
Volume21
Issue number2
Publication statusPublished - 2000

Fingerprint

Hepatocyte Growth Factor
Diabetic Retinopathy
Vascular Endothelial Growth Factor A
Light Coagulation
Vitreous Hemorrhage
Intercellular Signaling Peptides and Proteins
Retinal Detachment
Aqueous Humor
Traction
Membranes
Renal Hypertension
Therapeutic Uses
Diabetes Mellitus
Hemoglobins
Enzyme-Linked Immunosorbent Assay
Regression Analysis

Keywords

  • Aqueous humor
  • Diabetic retinopathy
  • Hepatocyte growth factor
  • Neovascularization
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Shinoda, K., Ishida, S., Kawashima, S., Wakabayashi, T., Uchita, M., Matsuzaki, T., ... Yamada, M. (2000). Clinical factors related to the aqueous levels of vascular endothelial growth factor and hepatocyte growth factor in proliferative diabetic retinopathy. Current Eye Research, 21(2), 655-661.

Clinical factors related to the aqueous levels of vascular endothelial growth factor and hepatocyte growth factor in proliferative diabetic retinopathy. / Shinoda, K.; Ishida, S.; Kawashima, S.; Wakabayashi, T.; Uchita, M.; Matsuzaki, T.; Takayama, Michiyo; Shinmura, K.; Yamada, M.

In: Current Eye Research, Vol. 21, No. 2, 2000, p. 655-661.

Research output: Contribution to journalArticle

Shinoda, K, Ishida, S, Kawashima, S, Wakabayashi, T, Uchita, M, Matsuzaki, T, Takayama, M, Shinmura, K & Yamada, M 2000, 'Clinical factors related to the aqueous levels of vascular endothelial growth factor and hepatocyte growth factor in proliferative diabetic retinopathy', Current Eye Research, vol. 21, no. 2, pp. 655-661.
Shinoda, K. ; Ishida, S. ; Kawashima, S. ; Wakabayashi, T. ; Uchita, M. ; Matsuzaki, T. ; Takayama, Michiyo ; Shinmura, K. ; Yamada, M. / Clinical factors related to the aqueous levels of vascular endothelial growth factor and hepatocyte growth factor in proliferative diabetic retinopathy. In: Current Eye Research. 2000 ; Vol. 21, No. 2. pp. 655-661.
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AU - Wakabayashi, T.

AU - Uchita, M.

AU - Matsuzaki, T.

AU - Takayama, Michiyo

AU - Shinmura, K.

AU - Yamada, M.

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AB - Purpose. To investigate clinical factors related to the aqueous humor levels of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with proliferative diabetic retinopathy (PDR). Methods. Undiluted aqueous humor was obtained during ocular surgery from 46 eyes of 46 patients and the levels of growth factors were measured using enzyme-linked immunosorbent assays. VEGF and HGF levels were compared with the number of photocoagulation. VEGF and HGF levels in patient groups stratified according to the existence of vitreous hemorrhage, retinal detachment, and fibrovascular membrane were analyzed. And clinical parameters associated with the growth factors were determined by multiple regression analysis. Results. The levels of VEGF decreased significantly as the extent of photocoagulation increased and showed significant positive correlation with the existence of vitreous hemorrhage. There was no significant correlation between VEGF levels and the existence of fibrovascular membrane and traction retinal detachment. The levels of HGF also decreased significantly as the extent of photocoagulation increased, but increased significantly when fibrovascular membrane existed. There were no significant correlations between HGF levels and the existence of vitreous hemorrhage and traction retinal detachment. Concerning systemic conditions, each growth factor has no significant correlation with duration and type of diabetes mellitus, the treatment regimen, the control of hemoglobin A1C, and the existences of hypertension or renal dysfunction. Conclusion. The therapeutic effect of panretinal photocoagulation on PDR might be partly exerted by reduction of the levels of VEGF and HGF in ocular fluid. Since the clinical parameters associated with VEGF were different from those associated with HGF, these growth factors might influence the progression of retinopathy in different ways.

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