Clinical features of post-polypectomy bleeding associated with heparin bridge therapy

Takuya Inoue, Tsutomu Nishida, Akira Maekawa, Yoshiki Tsujii, Tomofumi Akasaka, Motohiko Kato, Yoshito Hayashi, Shunsuke Yamamoto, Jumpei Kondo, Takuya Yamada, Shinichiro Shinzaki, Hideki Iijima, Masahiko Tsujii, Tetsuo Takehara

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background Heparin is given to patients undergoing colonoscopic polypectomy at high risk for thromboembolism. Little is known, however, about how heparin bridge therapy (HB) affects post-polypectomy bleeding (PPB). The present study aimed to identify the clinical features of PPB associated with HB. Patients and Methods Data of consecutive inpatients who underwent colonoscopic polypectomy with antithrombotic therapy at Osaka University Hospital were retrospectively collected and categorized into a HB group or a non-HB group. The incidence and characteristics of PPB were analyzed. Results A total of 117 patients with 279 lesions were identified, and the HB group included 45 patients. Nine of 10 patients with PPB were in the HB group, and the incidence of PPB was significantly higher in the HB group than in the non-HB group (20.0% vs 1.4%, respectively). PPB onset was later in the HB group than inthe non-HB group (median postoperative day: 4 vs 1, respectively). Five of the nine patients with PPB (55.6%) in the HB group experienced recurrent bleeding. One patient in the HB group required a blood transfusion as a result of massive PPB. All bleeding was eventually controlled endoscopically. Hospitalization was significantly longer in the HB group than in the non-HB group (median hospitalization: 14 vs 4 days, respectively). The univariate analysis showed that the predictors of PPB were warfarin use, HB and pedunculated polyps. Conclusions PPB associated with HB is characterized by high incidence, late onset and recurrent bleeding, resulting in long hospitalization.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalDigestive Endoscopy
Volume26
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Group Psychotherapy
Heparin
Hemorrhage
Therapeutics
Incidence
Hospitalization
Hospitalization Insurance
Thromboembolism
Warfarin
Polyps
Blood Transfusion
Inpatients

Keywords

  • antithrombotic agent
  • bleeding
  • colonic polyp
  • endoscopic surgery
  • heparin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Inoue, T., Nishida, T., Maekawa, A., Tsujii, Y., Akasaka, T., Kato, M., ... Takehara, T. (2014). Clinical features of post-polypectomy bleeding associated with heparin bridge therapy. Digestive Endoscopy, 26(2), 243-249. https://doi.org/10.1111/den.12123

Clinical features of post-polypectomy bleeding associated with heparin bridge therapy. / Inoue, Takuya; Nishida, Tsutomu; Maekawa, Akira; Tsujii, Yoshiki; Akasaka, Tomofumi; Kato, Motohiko; Hayashi, Yoshito; Yamamoto, Shunsuke; Kondo, Jumpei; Yamada, Takuya; Shinzaki, Shinichiro; Iijima, Hideki; Tsujii, Masahiko; Takehara, Tetsuo.

In: Digestive Endoscopy, Vol. 26, No. 2, 01.01.2014, p. 243-249.

Research output: Contribution to journalArticle

Inoue, T, Nishida, T, Maekawa, A, Tsujii, Y, Akasaka, T, Kato, M, Hayashi, Y, Yamamoto, S, Kondo, J, Yamada, T, Shinzaki, S, Iijima, H, Tsujii, M & Takehara, T 2014, 'Clinical features of post-polypectomy bleeding associated with heparin bridge therapy', Digestive Endoscopy, vol. 26, no. 2, pp. 243-249. https://doi.org/10.1111/den.12123
Inoue T, Nishida T, Maekawa A, Tsujii Y, Akasaka T, Kato M et al. Clinical features of post-polypectomy bleeding associated with heparin bridge therapy. Digestive Endoscopy. 2014 Jan 1;26(2):243-249. https://doi.org/10.1111/den.12123
Inoue, Takuya ; Nishida, Tsutomu ; Maekawa, Akira ; Tsujii, Yoshiki ; Akasaka, Tomofumi ; Kato, Motohiko ; Hayashi, Yoshito ; Yamamoto, Shunsuke ; Kondo, Jumpei ; Yamada, Takuya ; Shinzaki, Shinichiro ; Iijima, Hideki ; Tsujii, Masahiko ; Takehara, Tetsuo. / Clinical features of post-polypectomy bleeding associated with heparin bridge therapy. In: Digestive Endoscopy. 2014 ; Vol. 26, No. 2. pp. 243-249.
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abstract = "Background Heparin is given to patients undergoing colonoscopic polypectomy at high risk for thromboembolism. Little is known, however, about how heparin bridge therapy (HB) affects post-polypectomy bleeding (PPB). The present study aimed to identify the clinical features of PPB associated with HB. Patients and Methods Data of consecutive inpatients who underwent colonoscopic polypectomy with antithrombotic therapy at Osaka University Hospital were retrospectively collected and categorized into a HB group or a non-HB group. The incidence and characteristics of PPB were analyzed. Results A total of 117 patients with 279 lesions were identified, and the HB group included 45 patients. Nine of 10 patients with PPB were in the HB group, and the incidence of PPB was significantly higher in the HB group than in the non-HB group (20.0{\%} vs 1.4{\%}, respectively). PPB onset was later in the HB group than inthe non-HB group (median postoperative day: 4 vs 1, respectively). Five of the nine patients with PPB (55.6{\%}) in the HB group experienced recurrent bleeding. One patient in the HB group required a blood transfusion as a result of massive PPB. All bleeding was eventually controlled endoscopically. Hospitalization was significantly longer in the HB group than in the non-HB group (median hospitalization: 14 vs 4 days, respectively). The univariate analysis showed that the predictors of PPB were warfarin use, HB and pedunculated polyps. Conclusions PPB associated with HB is characterized by high incidence, late onset and recurrent bleeding, resulting in long hospitalization.",
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AU - Inoue, Takuya

AU - Nishida, Tsutomu

AU - Maekawa, Akira

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AU - Akasaka, Tomofumi

AU - Kato, Motohiko

AU - Hayashi, Yoshito

AU - Yamamoto, Shunsuke

AU - Kondo, Jumpei

AU - Yamada, Takuya

AU - Shinzaki, Shinichiro

AU - Iijima, Hideki

AU - Tsujii, Masahiko

AU - Takehara, Tetsuo

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N2 - Background Heparin is given to patients undergoing colonoscopic polypectomy at high risk for thromboembolism. Little is known, however, about how heparin bridge therapy (HB) affects post-polypectomy bleeding (PPB). The present study aimed to identify the clinical features of PPB associated with HB. Patients and Methods Data of consecutive inpatients who underwent colonoscopic polypectomy with antithrombotic therapy at Osaka University Hospital were retrospectively collected and categorized into a HB group or a non-HB group. The incidence and characteristics of PPB were analyzed. Results A total of 117 patients with 279 lesions were identified, and the HB group included 45 patients. Nine of 10 patients with PPB were in the HB group, and the incidence of PPB was significantly higher in the HB group than in the non-HB group (20.0% vs 1.4%, respectively). PPB onset was later in the HB group than inthe non-HB group (median postoperative day: 4 vs 1, respectively). Five of the nine patients with PPB (55.6%) in the HB group experienced recurrent bleeding. One patient in the HB group required a blood transfusion as a result of massive PPB. All bleeding was eventually controlled endoscopically. Hospitalization was significantly longer in the HB group than in the non-HB group (median hospitalization: 14 vs 4 days, respectively). The univariate analysis showed that the predictors of PPB were warfarin use, HB and pedunculated polyps. Conclusions PPB associated with HB is characterized by high incidence, late onset and recurrent bleeding, resulting in long hospitalization.

AB - Background Heparin is given to patients undergoing colonoscopic polypectomy at high risk for thromboembolism. Little is known, however, about how heparin bridge therapy (HB) affects post-polypectomy bleeding (PPB). The present study aimed to identify the clinical features of PPB associated with HB. Patients and Methods Data of consecutive inpatients who underwent colonoscopic polypectomy with antithrombotic therapy at Osaka University Hospital were retrospectively collected and categorized into a HB group or a non-HB group. The incidence and characteristics of PPB were analyzed. Results A total of 117 patients with 279 lesions were identified, and the HB group included 45 patients. Nine of 10 patients with PPB were in the HB group, and the incidence of PPB was significantly higher in the HB group than in the non-HB group (20.0% vs 1.4%, respectively). PPB onset was later in the HB group than inthe non-HB group (median postoperative day: 4 vs 1, respectively). Five of the nine patients with PPB (55.6%) in the HB group experienced recurrent bleeding. One patient in the HB group required a blood transfusion as a result of massive PPB. All bleeding was eventually controlled endoscopically. Hospitalization was significantly longer in the HB group than in the non-HB group (median hospitalization: 14 vs 4 days, respectively). The univariate analysis showed that the predictors of PPB were warfarin use, HB and pedunculated polyps. Conclusions PPB associated with HB is characterized by high incidence, late onset and recurrent bleeding, resulting in long hospitalization.

KW - antithrombotic agent

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KW - colonic polyp

KW - endoscopic surgery

KW - heparin

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