Clinical features of reversible posterior leukoencephalopathy syndrome in patients with systemic lupus erythematosus

Yuichiro Fujieda, Hiroshi Kataoka, Toshio Odani, Kotaro Otomo, Masaru Kato, Shinji Fukaya, Kenji Oku, Tetsuya Horita, Shinsuke Yasuda, Tatsuya Atsumi, Takao Koike

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

To characterize reversible posterior leukoencephalopathy syndrome (RPLS) in systemic lupus erythematosus (SLE) in terms of treatments for resolution and its clinical course, we reviewed 28 cases of RPLS in SLE including our cases in view of the treatment. Of these, 15 cases improved with blood pressure control and 13 required immunosuppressive therapy for activity of SLE presenting neurological manifestations. Patients without immunosuppressants at onset of RPLS more frequently required immunosuppressive therapy to recover it than those precedingly using these agents [31% (4/13) versus 87% (13/15), p = 0.008, chi-square test]. Brain magnetic resonance imaging (MRI) is important for diagnosis of RPLS-SLE in the patient with SLE who develops neurological disturbance and rapidly increasing blood pressure. When 7-day therapy for hypertension and convulsion does not reverse the manifestations, immunosuppressive treatments would be recommended to reverse RPLS.

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalModern rheumatology
Volume21
Issue number3
DOIs
Publication statusPublished - 2011 Jun
Externally publishedYes

Keywords

  • Magnetic resonance imaging (MRI)
  • Neuropsychiatric systemic lupus erythematosus (NPSLE)
  • Reversible posterior leukoencephalopathy syndrome (RPLS)
  • Systemic lupus erythematosus (SLE)

ASJC Scopus subject areas

  • Rheumatology

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