Clinical impact of women with gestational diabetes mellitus by the new consensus criteria: Two year experience in a single institution in Japan

Satoru Ikenoue, Kei Miyakoshi, Yoshifumi Saisho, Kensuke Sakai, Yoshifumi Kasuga, Marie Fukutake, Yoko Izumi, Tadashi Matsumoto, Kazuhiro Minegishi, Yasunori Yoshimura

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

There is a paucity of information on perinatal data regarding gestational diabetes mellitus (GDM) by the new criteria from a real experience because the number of health care associations implementing the new criteria is still limited. The aim of this study is to investigate perinatal features of the new criteria-defined GDM. We reviewed a total of 995 women with singleton pregnancy that underwent GDM screening followed by a diagnostic oral glucose tolerance test (OGTT). All women found to have GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. Of the 995 women, 141 had GDM (14.2%): 104 with one, 27 with two, and 10 with three abnormal OGTT values. Women with two or three abnormal OGTT values (2/3-AV) needed insulin treatment more frequently than those with one abnormal OGTT value (1-AV) (70.3% vs 23.1%, P<0.0001). After adjustment for age, pregravid overweight, gestational weeks at diagnosis, a first-degree family history of diabetes was correlated with the implementation of insulin treatment in women with 1-AV (adjusted odds ratio 3.9; 95% Confidence Interval 1.7-9.2; P = 0.001). When compared perinatal outcomes between women with normal glucose tolerance and GDM, fetal growth and the occurrence of pregnancy-induced hypertension were comparable between the two groups. Our data suggest that the IADPSG-defined GDM with 1-AV show less severe glucose intolerance, but might be at risk of insulin requirement when a first-degree family history of diabetes exists.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalEndocrine Journal
Volume61
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Gestational Diabetes
Consensus
Japan
Glucose Tolerance Test
Insulin
Blood Glucose Self-Monitoring
Pregnancy Induced Hypertension
Glucose Intolerance
Therapeutics
Fetal Development
Odds Ratio
Confidence Intervals
Delivery of Health Care
Glucose
Pregnancy

Keywords

  • Gestational diabetes mellitus
  • Gestational hypertension
  • Large-for gestational age
  • The new consensus criteria

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Clinical impact of women with gestational diabetes mellitus by the new consensus criteria : Two year experience in a single institution in Japan. / Ikenoue, Satoru; Miyakoshi, Kei; Saisho, Yoshifumi; Sakai, Kensuke; Kasuga, Yoshifumi; Fukutake, Marie; Izumi, Yoko; Matsumoto, Tadashi; Minegishi, Kazuhiro; Yoshimura, Yasunori.

In: Endocrine Journal, Vol. 61, No. 4, 2014, p. 353-358.

Research output: Contribution to journalArticle

Ikenoue, Satoru ; Miyakoshi, Kei ; Saisho, Yoshifumi ; Sakai, Kensuke ; Kasuga, Yoshifumi ; Fukutake, Marie ; Izumi, Yoko ; Matsumoto, Tadashi ; Minegishi, Kazuhiro ; Yoshimura, Yasunori. / Clinical impact of women with gestational diabetes mellitus by the new consensus criteria : Two year experience in a single institution in Japan. In: Endocrine Journal. 2014 ; Vol. 61, No. 4. pp. 353-358.
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