Clinical implications of noncoding indels in the surfactant‐encoding genes in lung cancer

Takahiro Nakagomi, Yosuke Hirotsu, Taichiro Goto, Daichi Shikata, Yujiro Yokoyama, Rumi Higuchi, Sotaro Otake, Kenji Amemiya, Toshio Oyama, Hitoshi Mochizuki, Masao Omata

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Abstract

Lung cancer arises from the accumulation of genetic mutations, usually in exons. A recent study identified indel mutations in the noncoding region of surfactant‐encoding genes in lung adenocarcinoma cases. In this study, we recruited 94 patients with 113 lung cancers (88 adenocarcinomas, 16 squamous cell carcinomas, and nine other histologies) who had undergone surgery in our department. A cancer panel was designed in‐house for analyzing the noncoding regions, and targeted sequencing was performed. Indels in the noncoding region of surfactantencoding genes were identified in 29/113 (25.7%) cases and represent the precise cell of origin for the lung cancer, irrespective of histological type and/or disease stage. In clinical practice, these indels may be used as clonal markers in patients with multiple cancers and to determine the origin of cancer of unknown primary site.

Original languageEnglish
Article number552
JournalCancers
Volume11
Issue number4
DOIs
Publication statusPublished - 2019 Apr

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Nakagomi, T., Hirotsu, Y., Goto, T., Shikata, D., Yokoyama, Y., Higuchi, R., Otake, S., Amemiya, K., Oyama, T., Mochizuki, H., & Omata, M. (2019). Clinical implications of noncoding indels in the surfactant‐encoding genes in lung cancer. Cancers, 11(4), [552]. https://doi.org/10.3390/cancers11040552