Clinical Implications of Tumor Size and Local Extent of Primary Prostatic Lesions in Prostate Cancer Patients with Metastases: Value of Endorectal Magnetic Resonance Imaging in Patients with Metastases

Jun Nakashima, Akihiro Tanimoto, Eiji Kikuchi, Akira Miyajima, Ken Nakagawa, Mototsugu Oya, Takashi Ohigashi, Masaru Murai

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2 Citations (Scopus)

Abstract

Objectives: To investigate the clinical significance of local assessment by endorectal magnetic resonance imaging (MRI) in prostate cancer patients with metastases. Methods: The local extent and tumor size were determined by endorectal MRI in 95 prostate cancer patients with metastases, and their clinical implications were assessed. Results: The maximum diameter and tumor volume significantly correlated with the local extent of disease but not with extent of disease (EOD) on bone scan. In univariate analyses, EOD, serum prostate-specific antigen level, serum alkaline phosphatase level, and hemoglobin level were significantly associated with disease-specific survival, whereas tumor size and local extent of primary lesions were not. In a multivariate analysis EOD on bone scan was a significant prognostic factor. Conclusions: Tumor size and local extent of the primary lesion estimated by endorectal MRI were not associated with disease-specific survival. Assessment of the primary lesion by endorectal MRI is of limited value in predicting the prognosis of prostate cancer patients with metastases.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalUrology
Volume70
Issue number1
DOIs
Publication statusPublished - 2007 Jul 1

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ASJC Scopus subject areas

  • Urology

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