Clinical importance of Stenotrophomonas maltophilia nosocomial pneumonia due to its high mortality in hemodialysis patients

Shu Wakino, Eiko Imai, Kyoko Yoshioka, Tadashi Kamayachi, Hitoshi Minakuchi, Koichi Hayashi, Hajime Inamoto, Hiroshi Itoh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Patients undergoing hemodialysis are immunocompromized and can suffer from pneumonia with various pathogens in nosocomial conditions. We investigated the fundamental information on the characteristics of hemodialysis inpatients and nosocomial pneumonia. We surveyed 1803 hemodialysis patients admitted to our university hospital between 2001 and 2007. The mean patient age was 64.8 years and the average period of hospitalization was 28.1 days, which was considerably longer than the average stay in our hospital (14.2 days). Patients were admitted to many different departments and for various reasons. We isolated 391 microorganisms from the sputum of 120 pneumonia patients undergoing hemodialysis, including Candida albicans, methicillin-resistant Staphylococcus aureus, and Staphylococcus epidermidis, which were the leading three isolates. From these 120 patients, a total of 199 pathogens were identified as being responsible for the pneumonia. Multi-drug resistant Stenotrophomonas maltophilia was found to be susceptible to a new fluoroquinolone, but is resistant to older generation quinolones. Out of the 120 patients with pneumonia, 12 out of 18 patients infected with S. maltophilia died, indicating the highest fatality rate for this pathogen. In this survey, we found that hemodialysis patients were hospitalized for long periods, and for various reasons in many departments. They suffered from nosocomial pneumonia caused by multi-drug resistant pathogens, including S. maltophilia. For pneumonia due to S. maltophilia, new generation fluoroquinolones can be the treatment of choice, although S. maltophilia-related pneumonia should be treated very carefully because of its high fatality rate.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalTherapeutic Apheresis and Dialysis
Volume13
Issue number3
DOIs
Publication statusPublished - 2009 Jun

Fingerprint

Stenotrophomonas maltophilia
Renal Dialysis
Pneumonia
Mortality
Fluoroquinolones
Staphylococcus epidermidis
Quinolones
Methicillin-Resistant Staphylococcus aureus
Sputum
Candida albicans
Pharmaceutical Preparations
Inpatients
Hospitalization

Keywords

  • Fatality
  • Hemodialysis
  • Multi-drug esistance
  • Nosocomial pneumonia
  • Quinolone
  • Stenotrophomonas maltophilia

ASJC Scopus subject areas

  • Hematology
  • Nephrology

Cite this

Clinical importance of Stenotrophomonas maltophilia nosocomial pneumonia due to its high mortality in hemodialysis patients. / Wakino, Shu; Imai, Eiko; Yoshioka, Kyoko; Kamayachi, Tadashi; Minakuchi, Hitoshi; Hayashi, Koichi; Inamoto, Hajime; Itoh, Hiroshi.

In: Therapeutic Apheresis and Dialysis, Vol. 13, No. 3, 06.2009, p. 193-198.

Research output: Contribution to journalArticle

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