Clinical information on serum IGFBP-3 levels and IGFBP-3 proteolytic activity in childhood

Yukihiro Hasegawa, Tomonobu Hasegawa, Katsura Fujii, Hideko Konii, Makoto Anzo, Taiji Aso, Shinobu Kotoh, Yutaka Tsuchiya

Research output: Contribution to journalArticle

4 Citations (Scopus)


In this review paper, three pieces of clinical information in childhood are presented: (1) IGFBP-3 may replace GH provocation tests in the diagnosis of GH deficiency (GHD); (2) IGFBP-3 levels are regulated by IGF-I levels in a short period, and (3) ratio of free IGF-I to total IGF-I is high in serum of early infancy, similarly to serum of pregnancy, only partially owing to the presence of IGFBP-3 proteolytic activity. Each paper will be published soon.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalProgress in Growth Factor Research
Issue number2-4
Publication statusPublished - 1995



  • IGFBP-3
  • IGFBP-3 proteolytic activity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this