Clinical management of epithelial ovarian cancer

Yusuke Kobayashi, Hiroyuki Nomura, Fumio Kataoka, Eiichirou Tominaga, Kouji Banno, Daisuke Aoki

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ovarian cancer has high morbidity and mortality worldwide, and its mortality is the highest among female genital cancers. Improvement in clinical outcome is an urgent issue for ovarian cancer, and clinical management including treatment has been repeatedly studied. Tumor markers such as CA125, CA19-9, and HE4 and image diagnosis using MRI, CT, PET, etc. are indispensable diagnostic aid tools. In the initial treatment, primary debulking surgery (PDS) is basically effective, but fertility preservation can be considered depending on the case. For advanced cancers, interval debulking surgery (IDS) is considered after several cycles of neoadjuvant chemotherapy (NAC). Although the combination of paclitaxel and carboplatin (TC) regimen was originally established as the standard chemotherapy for ovarian cancer regardless of tissue type, new treatments in clinical trials, including molecular-targeted therapeutic agents, are being investigated. The main treatment for recurrent cancer is chemotherapy, and sensitivity to chemotherapy based on the disease-free interval has been considered in the choice of treatment. Furthermore, in recent years, risk-reducing bilateral salpingo-oophorectomy has been undertaken to prevent the onset of hereditary breast and ovarian cancer. It is also being studied how to manage the follow-up after treatment and hormone replacement.

Original languageEnglish
Title of host publicationCell Biology of the Ovary
Subtitle of host publicationStem Cells, Development, Cancer, and Clinical Aspects
PublisherSpringer Singapore
Pages135-151
Number of pages17
ISBN (Electronic)9789811079412
ISBN (Print)9789811079405
DOIs
Publication statusPublished - 2018 Jun 12

Keywords

  • Adjuvant chemotherapy
  • Diagnostic imaging
  • Follow-up after treatment
  • Hormone replacement therapy
  • Interval debulking surgery
  • Molecular-targeted drugs
  • Neoadjuvant chemotherapy
  • Primary debulking surgery
  • Risk-reducing salpingo-oophorectomy
  • Staging laparotomy
  • Tumor marker

ASJC Scopus subject areas

  • Medicine(all)
  • Health Professions(all)

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