Clinical, microbiological, and immunological studies following initial preparation in adult periodontitis.

Taneaki Nakagawa, S. Yamada, M. Tsunoda, T. Sato, Y. Naito, I. Takazoe, K. Okuda

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Abstract

This study investigated the clinical, microbiological and immunological changes induced in adult periodontitis by initial preparation. Microflora in periodontal lesions was mainly examined by cultural methods, and serum IgG antibody levels were measured by an enzyme linked immunosorbent assay. Black-pigmented gram negative anaerobes, especially Porphyromonas (Bacteroides) gingivalis, was predominant in periodontal pockets with adult destructive periodontitis. Significantly elevated serum IgG antibody levels to P. gingivalis was found in high frequency, and these serum IgG antibody levels correlated with the presence of P. gingivalis in periodontal pockets, not with other bacteria tested. Total-CFU was significantly reduced and clinical conditions were improved after supragingival plaque control, but the microflora themselves showed few changes. Although reduction of total-CFU and changes in microflora were observed following scaling and root planing, it was found to be difficult to completely eliminate periodontopathic bacteria from periodontal pockets. Although serum IgG antibody levels to P. gingivalis was significantly reduced following initial preparation, the levels were still elevated from those of the controls. It was found that the presence of P. gingivalis was correlated with clinical conditions, including bleeding on probing and residual pocket depth following initial preparation.

Original languageEnglish
Pages (from-to)321-331
Number of pages11
JournalThe Bulletin of Tokyo Dental College
Volume31
Issue number4
Publication statusPublished - 1990 Nov
Externally publishedYes

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Chronic Periodontitis
Periodontal Pocket
Immunoglobulin G
Porphyromonas gingivalis
Antibodies
Serum
Root Planing
Bacteria
Enzyme-Linked Immunosorbent Assay
Hemorrhage

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical, microbiological, and immunological studies following initial preparation in adult periodontitis. / Nakagawa, Taneaki; Yamada, S.; Tsunoda, M.; Sato, T.; Naito, Y.; Takazoe, I.; Okuda, K.

In: The Bulletin of Tokyo Dental College, Vol. 31, No. 4, 11.1990, p. 321-331.

Research output: Contribution to journalArticle

Nakagawa, T, Yamada, S, Tsunoda, M, Sato, T, Naito, Y, Takazoe, I & Okuda, K 1990, 'Clinical, microbiological, and immunological studies following initial preparation in adult periodontitis.', The Bulletin of Tokyo Dental College, vol. 31, no. 4, pp. 321-331.
Nakagawa, Taneaki ; Yamada, S. ; Tsunoda, M. ; Sato, T. ; Naito, Y. ; Takazoe, I. ; Okuda, K. / Clinical, microbiological, and immunological studies following initial preparation in adult periodontitis. In: The Bulletin of Tokyo Dental College. 1990 ; Vol. 31, No. 4. pp. 321-331.
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