Clinical outcome in patients with small intestinal non-Hodgkin lymphoma

Shinichi Kako; Kumi Oshima; Miki Sato; Kiriko Terasako; Shinya Okuda; Hideki Nakasone; Rie Yamazaki; Yukie Tanaka; Aki Tanihara; Yutaka Kawamura; Hirokazu Kiyosaki; Takakazu Higuchi; Junji Nishida; Fumio Konishi; Yoshinobu Kanda

doi:10.1080/10428190903147629

Clinical outcome in patients with small intestinal non-Hodgkin lymphoma

Shinichi Kako, Kumi Oshima, Miki Sato, Kiriko Terasako, Shinya Okuda, Hideki Nakasone, Rie Yamazaki, Yukie Tanaka, Aki Tanihara, Yutaka Kawamura, Hirokazu Kiyosaki, Takakazu Higuchi, Junji Nishida, Fumio Konishi, Yoshinobu Kanda

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The clinical features and outcome of small intestinal lymphoma remain unclear. We retrospectively analyzed 23 patients who had non-Hodgkin lymphoma with a small intestinal lesion. With a median follow-up of 37 months, the 5-year overall survival and failure-free survival (FFS) were 64% and 60%, respectively. In a univariate analysis, a worse performance status at the start of treatment and the occurrence of abdominal symptoms or perforation during treatment were associated with poor survival. Perforation often resulted in a dismal prognosis in patients with uncontrollable lymphoma, but not in patients with lymphoma in remission. The role of surgery in small intestinal lymphoma remains equivocal. In the current study, surgery before other therapies favorably influenced FFS, and all patients who underwent complete resection of the small intestinal lesion had extremely favorable results. Further studies are warranted to establish optimal therapeutic strategies.

Original language	English
Pages (from-to)	1618-1624
Number of pages	7
Journal	Leukemia and Lymphoma
Volume	50
Issue number	10
DOIs	https://doi.org/10.1080/10428190903147629
Publication status	Published - 2009
Externally published	Yes

Keywords

Abdominal symptoms
Perforation
Small intestinal lymphoma
Surgical procedure

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428190903147629

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title = "Clinical outcome in patients with small intestinal non-Hodgkin lymphoma",

abstract = "The clinical features and outcome of small intestinal lymphoma remain unclear. We retrospectively analyzed 23 patients who had non-Hodgkin lymphoma with a small intestinal lesion. With a median follow-up of 37 months, the 5-year overall survival and failure-free survival (FFS) were 64% and 60%, respectively. In a univariate analysis, a worse performance status at the start of treatment and the occurrence of abdominal symptoms or perforation during treatment were associated with poor survival. Perforation often resulted in a dismal prognosis in patients with uncontrollable lymphoma, but not in patients with lymphoma in remission. The role of surgery in small intestinal lymphoma remains equivocal. In the current study, surgery before other therapies favorably influenced FFS, and all patients who underwent complete resection of the small intestinal lesion had extremely favorable results. Further studies are warranted to establish optimal therapeutic strategies.",

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AU - Kako, Shinichi

AU - Oshima, Kumi

AU - Sato, Miki

AU - Terasako, Kiriko

AU - Okuda, Shinya

AU - Nakasone, Hideki

AU - Yamazaki, Rie

AU - Tanaka, Yukie

AU - Tanihara, Aki

AU - Kawamura, Yutaka

AU - Kiyosaki, Hirokazu

AU - Higuchi, Takakazu

AU - Nishida, Junji

AU - Konishi, Fumio

AU - Kanda, Yoshinobu

PY - 2009

Y1 - 2009

N2 - The clinical features and outcome of small intestinal lymphoma remain unclear. We retrospectively analyzed 23 patients who had non-Hodgkin lymphoma with a small intestinal lesion. With a median follow-up of 37 months, the 5-year overall survival and failure-free survival (FFS) were 64% and 60%, respectively. In a univariate analysis, a worse performance status at the start of treatment and the occurrence of abdominal symptoms or perforation during treatment were associated with poor survival. Perforation often resulted in a dismal prognosis in patients with uncontrollable lymphoma, but not in patients with lymphoma in remission. The role of surgery in small intestinal lymphoma remains equivocal. In the current study, surgery before other therapies favorably influenced FFS, and all patients who underwent complete resection of the small intestinal lesion had extremely favorable results. Further studies are warranted to establish optimal therapeutic strategies.

AB - The clinical features and outcome of small intestinal lymphoma remain unclear. We retrospectively analyzed 23 patients who had non-Hodgkin lymphoma with a small intestinal lesion. With a median follow-up of 37 months, the 5-year overall survival and failure-free survival (FFS) were 64% and 60%, respectively. In a univariate analysis, a worse performance status at the start of treatment and the occurrence of abdominal symptoms or perforation during treatment were associated with poor survival. Perforation often resulted in a dismal prognosis in patients with uncontrollable lymphoma, but not in patients with lymphoma in remission. The role of surgery in small intestinal lymphoma remains equivocal. In the current study, surgery before other therapies favorably influenced FFS, and all patients who underwent complete resection of the small intestinal lesion had extremely favorable results. Further studies are warranted to establish optimal therapeutic strategies.

KW - Abdominal symptoms

KW - Perforation

KW - Small intestinal lymphoma

KW - Surgical procedure

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IS - 10

ER -

Clinical outcome in patients with small intestinal non-Hodgkin lymphoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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