TY - JOUR
T1 - Clinical outcome of patients with schizophrenia without maintenance treatment in a nonindustrialized society
AU - Kurihara, Toshiyuki
AU - Kato, Motoichiro
AU - Reverger, Robert
AU - Yagi, Gohei
PY - 2002
Y1 - 2002
N2 - The outcome of 51 patients with schizophrenia (DSM-III-R) consecutively admitted to Bangli State Mental Hospital (Bali) with no prior psychiatric treatment was assessed by the Positive and Negative Syndrome Scale (PANSS) and Eguma's Social Adjustment Scale (ESAS) at a 5-year followup evaluation. The subjects were divided into two groups according to their medication patterns determined at the assessment. Mann-Whitney U test revealed no significant differences in the PANSS scores between the treated group (n = 22) and the nontreated group (n = 29), whereas a significant difference in the distribution of the scores was observed (Kolomorov-Smirnoff test, p < 0.05). Subjects in the nontreated group showed a greater tendency to be scored either high or low in the PANSS than did subjects in the treated group. Moreover, subjects in the nontreated group tended to be classified more often into the best or worst outcome categories when the ESAS was performed than subjects in the treated group (chi-square analysis, p < 0.05). In the present study, nontreatment may reflect a good outcome in terms of no requirement for continuing treatment but still be causally related to poor outcome in terms of absence of the necessary treatment. The results suggest the importance of therapeutic intervention for schizophrenia patients who have severe psychopathology without maintenance treatment in nonindustrialized societies.
AB - The outcome of 51 patients with schizophrenia (DSM-III-R) consecutively admitted to Bangli State Mental Hospital (Bali) with no prior psychiatric treatment was assessed by the Positive and Negative Syndrome Scale (PANSS) and Eguma's Social Adjustment Scale (ESAS) at a 5-year followup evaluation. The subjects were divided into two groups according to their medication patterns determined at the assessment. Mann-Whitney U test revealed no significant differences in the PANSS scores between the treated group (n = 22) and the nontreated group (n = 29), whereas a significant difference in the distribution of the scores was observed (Kolomorov-Smirnoff test, p < 0.05). Subjects in the nontreated group showed a greater tendency to be scored either high or low in the PANSS than did subjects in the treated group. Moreover, subjects in the nontreated group tended to be classified more often into the best or worst outcome categories when the ESAS was performed than subjects in the treated group (chi-square analysis, p < 0.05). In the present study, nontreatment may reflect a good outcome in terms of no requirement for continuing treatment but still be causally related to poor outcome in terms of absence of the necessary treatment. The results suggest the importance of therapeutic intervention for schizophrenia patients who have severe psychopathology without maintenance treatment in nonindustrialized societies.
KW - Developing countries
KW - Duration of untreated psychosis (DUP)
KW - Maintenance treatment
KW - Outcome assessment
KW - Schizophrenia
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U2 - 10.1093/oxfordjournals.schbul.a006958
DO - 10.1093/oxfordjournals.schbul.a006958
M3 - Article
C2 - 12645682
AN - SCOPUS:0036992181
VL - 28
SP - 515
EP - 524
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
SN - 0586-7614
IS - 3
ER -