Clinical presentation and diagnosis of toxoplasmic encephalitis in Japan

Naoya Sakamoto, Takuya Maeda, Kei Mikita, Yasuyuki Kato, Naoki Yanagisawa, Akihiko Suganuma, Akifumi Imamura, Fukumi Nakamura-Uchiyama, Yasushi Miyahira, Akihiko Kawana, Kenji Ohnishi, Atsushi Ajisawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Distinguishing life-threatening toxoplasmic encephalitis (TE) from brain lymphoma in patients with acquired immunodeficiency syndrome (AIDS) may be difficult. Empiric anti-toxoplasmosis treatment is often initiated because of the reluctance in performing brain biopsies, which may delay the diagnosis and treatment of brain lymphoma in Japan. In this study, we retrospectively examined the clinical characteristics of 13 AIDS patients with TE in Japan, including magnetic resonance imaging and thallium 201 (201TI) single photon emission computed tomography (SPECT) findings, cerebral spinal fluid analysis, serology, and polymerase chain reaction (PCR) results. All patients improved on anti-toxoplasmosis treatment. Of the 11 patients who underwent serological testing, 6 (55%) had a positive serological result. Of the 7 patients who underwent PCR testing, 3 (42.9%) had a positive PCR result. Nine of 11 patients with TE (81.8%) had multiple lesions. Analysis of the sites of TE lesions did not reveal a difference in site predilection between TE and brain lymphoma. Uptake was negative in all 9 patients who underwent 201Tl SPECT. The study findings suggest that toxoplasma serostatus and PCR may be used to discriminate TE from brain lymphoma. No focal accumulation of 201TI is strongly suggestive of TE in patients with AIDS in Japan.

Original languageEnglish
Pages (from-to)701-704
Number of pages4
JournalParasitology International
Volume63
Issue number5
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Encephalitis
Japan
Lymphoma
Brain
Polymerase Chain Reaction
Acquired Immunodeficiency Syndrome
Toxoplasmosis
Single-Photon Emission-Computed Tomography
Thallium
Toxoplasma
Serology
Therapeutics
Magnetic Resonance Imaging
Biopsy

Keywords

  • AIDS
  • PCR
  • SPECT
  • Toxoplasmic encephalitis
  • Toxoplasmosis

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Medicine(all)

Cite this

Sakamoto, N., Maeda, T., Mikita, K., Kato, Y., Yanagisawa, N., Suganuma, A., ... Ajisawa, A. (2014). Clinical presentation and diagnosis of toxoplasmic encephalitis in Japan. Parasitology International, 63(5), 701-704. https://doi.org/10.1016/j.parint.2014.05.007

Clinical presentation and diagnosis of toxoplasmic encephalitis in Japan. / Sakamoto, Naoya; Maeda, Takuya; Mikita, Kei; Kato, Yasuyuki; Yanagisawa, Naoki; Suganuma, Akihiko; Imamura, Akifumi; Nakamura-Uchiyama, Fukumi; Miyahira, Yasushi; Kawana, Akihiko; Ohnishi, Kenji; Ajisawa, Atsushi.

In: Parasitology International, Vol. 63, No. 5, 2014, p. 701-704.

Research output: Contribution to journalArticle

Sakamoto, N, Maeda, T, Mikita, K, Kato, Y, Yanagisawa, N, Suganuma, A, Imamura, A, Nakamura-Uchiyama, F, Miyahira, Y, Kawana, A, Ohnishi, K & Ajisawa, A 2014, 'Clinical presentation and diagnosis of toxoplasmic encephalitis in Japan', Parasitology International, vol. 63, no. 5, pp. 701-704. https://doi.org/10.1016/j.parint.2014.05.007
Sakamoto, Naoya ; Maeda, Takuya ; Mikita, Kei ; Kato, Yasuyuki ; Yanagisawa, Naoki ; Suganuma, Akihiko ; Imamura, Akifumi ; Nakamura-Uchiyama, Fukumi ; Miyahira, Yasushi ; Kawana, Akihiko ; Ohnishi, Kenji ; Ajisawa, Atsushi. / Clinical presentation and diagnosis of toxoplasmic encephalitis in Japan. In: Parasitology International. 2014 ; Vol. 63, No. 5. pp. 701-704.
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