Abstract
We performed two studies to investigate the clinical roles of VEGF and HGF in diabetes mellitus. (1) Serum concentrations of VEGF and HGF were measured in type-2 diabetic patients (DM, n = 74) and control subjects (C, n = 44) by enzyme-linked immunosorbent assay, and their relationship to fasting plasma glucose (FPG), hemoglobin Aic, total cholesterol, high-density lipoprotein cholesterol (HDL-C), liver function, systolic blood pressure, smoking, and diabetic angiopathy were analyzed. (2) VEGF and HGF concentrations were measured in both the serum and anterior aqueous humor of type-2 diabetic patients (n = 33) and non-diabetic patients (n = 12) who underwent eye surgery, and their correlations with diabetic retinopathy were determined. (1) There were no differences in serum VEGF between C and DM, but, serum VEGF was significantly higher in DM with diabetic angiopathy. Serum HGF was higher in DM and smokers, and inversely correlated with HDL-C and FPG. (2) Neither serum VEGF nor HGF were associated with retinopathy, but anterior aqueous humor VEGF was extremely higher and HGF tended to be higher in DM with preproliferative diabetic retinopathy. VEGF and HGF were not correlated in serum, but a positive correlation was observed in anterior aqueous humor. These results suggest that VEGF and HGF affect diabetic retinopathy, however, no relationship to diabetic macroangiopathy could be detected.
| Original language | English |
|---|---|
| Pages (from-to) | 347-354 |
| Number of pages | 8 |
| Journal | Journal of the Japan Diabetes Society |
| Volume | 43 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2000 |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Clinical Role of Vascular Endothelial Growth Factor (VEGF) and Hepatocyte Growth Factor (HGF) in Type-2 Diabetic Patients. / Takayama, Michiyo; Shinmura, Ken; Hasegawa, Hiroshi; Tani, Masato; Wakabayashi, Toshiko; Shinoda, Kei; Ishida, Susumu; Yamada, Masakazu.
In: Journal of the Japan Diabetes Society, Vol. 43, No. 5, 2000, p. 347-354.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical Role of Vascular Endothelial Growth Factor (VEGF) and Hepatocyte Growth Factor (HGF) in Type-2 Diabetic Patients
AU - Takayama, Michiyo
AU - Shinmura, Ken
AU - Hasegawa, Hiroshi
AU - Tani, Masato
AU - Wakabayashi, Toshiko
AU - Shinoda, Kei
AU - Ishida, Susumu
AU - Yamada, Masakazu
PY - 2000
Y1 - 2000
N2 - We performed two studies to investigate the clinical roles of VEGF and HGF in diabetes mellitus. (1) Serum concentrations of VEGF and HGF were measured in type-2 diabetic patients (DM, n = 74) and control subjects (C, n = 44) by enzyme-linked immunosorbent assay, and their relationship to fasting plasma glucose (FPG), hemoglobin Aic, total cholesterol, high-density lipoprotein cholesterol (HDL-C), liver function, systolic blood pressure, smoking, and diabetic angiopathy were analyzed. (2) VEGF and HGF concentrations were measured in both the serum and anterior aqueous humor of type-2 diabetic patients (n = 33) and non-diabetic patients (n = 12) who underwent eye surgery, and their correlations with diabetic retinopathy were determined. (1) There were no differences in serum VEGF between C and DM, but, serum VEGF was significantly higher in DM with diabetic angiopathy. Serum HGF was higher in DM and smokers, and inversely correlated with HDL-C and FPG. (2) Neither serum VEGF nor HGF were associated with retinopathy, but anterior aqueous humor VEGF was extremely higher and HGF tended to be higher in DM with preproliferative diabetic retinopathy. VEGF and HGF were not correlated in serum, but a positive correlation was observed in anterior aqueous humor. These results suggest that VEGF and HGF affect diabetic retinopathy, however, no relationship to diabetic macroangiopathy could be detected.
AB - We performed two studies to investigate the clinical roles of VEGF and HGF in diabetes mellitus. (1) Serum concentrations of VEGF and HGF were measured in type-2 diabetic patients (DM, n = 74) and control subjects (C, n = 44) by enzyme-linked immunosorbent assay, and their relationship to fasting plasma glucose (FPG), hemoglobin Aic, total cholesterol, high-density lipoprotein cholesterol (HDL-C), liver function, systolic blood pressure, smoking, and diabetic angiopathy were analyzed. (2) VEGF and HGF concentrations were measured in both the serum and anterior aqueous humor of type-2 diabetic patients (n = 33) and non-diabetic patients (n = 12) who underwent eye surgery, and their correlations with diabetic retinopathy were determined. (1) There were no differences in serum VEGF between C and DM, but, serum VEGF was significantly higher in DM with diabetic angiopathy. Serum HGF was higher in DM and smokers, and inversely correlated with HDL-C and FPG. (2) Neither serum VEGF nor HGF were associated with retinopathy, but anterior aqueous humor VEGF was extremely higher and HGF tended to be higher in DM with preproliferative diabetic retinopathy. VEGF and HGF were not correlated in serum, but a positive correlation was observed in anterior aqueous humor. These results suggest that VEGF and HGF affect diabetic retinopathy, however, no relationship to diabetic macroangiopathy could be detected.
UR - http://www.scopus.com/inward/record.url?scp=85024740747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85024740747&partnerID=8YFLogxK
U2 - 10.11213/tonyobyo1958.43.347
DO - 10.11213/tonyobyo1958.43.347
M3 - Article
AN - SCOPUS:85024740747
VL - 43
SP - 347
EP - 354
JO - Journal of the Japan Diabetes Society
JF - Journal of the Japan Diabetes Society
SN - 0021-437X
IS - 5
ER -