Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE)

K. Aoki, T. Takeuchi, I. Itoh, Y. Takano, T. Itoh, O. Hosono, J. Koide, T. Abe

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Abstract

Anti-cardiolipin antibody (aCL) in SLE patients reacts with cardiolipin/beta 2-GP1 complex. In order to disclose clinical significance of aCL in patients with SLE, aCL was determined by newly-developed anti-CL.beta 2-GP1 kit [Yamasa] EIA in 58 patients with SLE and the relationship between clinical manifestation of SLE and the presence of aCL was examined. Anti-cardiolipin antibody was positive in 20 patients (34.5%). In 20 SLE patients with positive aCL, livedo reticularis in 7, retinal vein thrombosis in 3, thrombophlebitis in 3 and other vasculo-occlusive episodes were observed as a characteristic clinical features of positive aCL. In contrast, a SLE patient complicated by ileal perforation due to necrotizing angiitis had negative aCL. Other clinical and laboratory features associated with aCL include recurrent fetal loss and thrombocytopenia.

Original languageEnglish
Pages (from-to)961-966
Number of pages6
JournalRyūmachi. [Rheumatism]
Volume34
Issue number6
Publication statusPublished - 1994 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology

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    Aoki, K., Takeuchi, T., Itoh, I., Takano, Y., Itoh, T., Hosono, O., Koide, J., & Abe, T. (1994). Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE). Ryūmachi. [Rheumatism], 34(6), 961-966.