Abstract
Anti-cardiolipin antibody (aCL) in SLE patients reacts with cardiolipin/beta 2-GP1 complex. In order to disclose clinical significance of aCL in patients with SLE, aCL was determined by newly-developed anti-CL.beta 2-GP1 kit [Yamasa] EIA in 58 patients with SLE and the relationship between clinical manifestation of SLE and the presence of aCL was examined. Anti-cardiolipin antibody was positive in 20 patients (34.5%). In 20 SLE patients with positive aCL, livedo reticularis in 7, retinal vein thrombosis in 3, thrombophlebitis in 3 and other vasculo-occlusive episodes were observed as a characteristic clinical features of positive aCL. In contrast, a SLE patient complicated by ileal perforation due to necrotizing angiitis had negative aCL. Other clinical and laboratory features associated with aCL include recurrent fetal loss and thrombocytopenia.
| Original language | English |
|---|---|
| Pages (from-to) | 961-966 |
| Number of pages | 6 |
| Journal | Ryumachi |
| Volume | 34 |
| Issue number | 6 |
| Publication status | Published - 1994 Dec |
| Externally published | Yes |
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ASJC Scopus subject areas
- Rheumatology
Cite this
Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE). / Aoki, K.; Takeuchi, Tsutomu; Itoh, I.; Takano, Y.; Itoh, T.; Hosono, O.; Koide, J.; Abe, T.
In: Ryumachi, Vol. 34, No. 6, 12.1994, p. 961-966.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE)
AU - Aoki, K.
AU - Takeuchi, Tsutomu
AU - Itoh, I.
AU - Takano, Y.
AU - Itoh, T.
AU - Hosono, O.
AU - Koide, J.
AU - Abe, T.
PY - 1994/12
Y1 - 1994/12
N2 - Anti-cardiolipin antibody (aCL) in SLE patients reacts with cardiolipin/beta 2-GP1 complex. In order to disclose clinical significance of aCL in patients with SLE, aCL was determined by newly-developed anti-CL.beta 2-GP1 kit [Yamasa] EIA in 58 patients with SLE and the relationship between clinical manifestation of SLE and the presence of aCL was examined. Anti-cardiolipin antibody was positive in 20 patients (34.5%). In 20 SLE patients with positive aCL, livedo reticularis in 7, retinal vein thrombosis in 3, thrombophlebitis in 3 and other vasculo-occlusive episodes were observed as a characteristic clinical features of positive aCL. In contrast, a SLE patient complicated by ileal perforation due to necrotizing angiitis had negative aCL. Other clinical and laboratory features associated with aCL include recurrent fetal loss and thrombocytopenia.
AB - Anti-cardiolipin antibody (aCL) in SLE patients reacts with cardiolipin/beta 2-GP1 complex. In order to disclose clinical significance of aCL in patients with SLE, aCL was determined by newly-developed anti-CL.beta 2-GP1 kit [Yamasa] EIA in 58 patients with SLE and the relationship between clinical manifestation of SLE and the presence of aCL was examined. Anti-cardiolipin antibody was positive in 20 patients (34.5%). In 20 SLE patients with positive aCL, livedo reticularis in 7, retinal vein thrombosis in 3, thrombophlebitis in 3 and other vasculo-occlusive episodes were observed as a characteristic clinical features of positive aCL. In contrast, a SLE patient complicated by ileal perforation due to necrotizing angiitis had negative aCL. Other clinical and laboratory features associated with aCL include recurrent fetal loss and thrombocytopenia.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028719290&partnerID=8YFLogxK
M3 - Article
VL - 34
SP - 961
EP - 966
JO - Ryumachi
JF - Ryumachi
SN - 0300-9157
IS - 6
ER -