Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE)

K. Aoki; T. Takeuchi; I. Itoh; Y. Takano; T. Itoh; O. Hosono; J. Koide; T. Abe

Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE)

K. Aoki, T. Takeuchi, I. Itoh, Y. Takano, T. Itoh, O. Hosono, J. Koide, T. Abe

Research output: Contribution to journal › Article › peer-review

Abstract

Anti-cardiolipin antibody (aCL) in SLE patients reacts with cardiolipin/beta 2-GP1 complex. In order to disclose clinical significance of aCL in patients with SLE, aCL was determined by newly-developed anti-CL.beta 2-GP1 kit [Yamasa] EIA in 58 patients with SLE and the relationship between clinical manifestation of SLE and the presence of aCL was examined. Anti-cardiolipin antibody was positive in 20 patients (34.5%). In 20 SLE patients with positive aCL, livedo reticularis in 7, retinal vein thrombosis in 3, thrombophlebitis in 3 and other vasculo-occlusive episodes were observed as a characteristic clinical features of positive aCL. In contrast, a SLE patient complicated by ileal perforation due to necrotizing angiitis had negative aCL. Other clinical and laboratory features associated with aCL include recurrent fetal loss and thrombocytopenia.

Original language	English
Pages (from-to)	961-966
Number of pages	6
Journal	Ryūmachi. [Rheumatism]
Volume	34
Issue number	6
Publication status	Published - 1994 Dec
Externally published	Yes

ASJC Scopus subject areas

Rheumatology

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@article{364120977fe3415e8abc043bb86b87ec,

title = "Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE)",

abstract = "Anti-cardiolipin antibody (aCL) in SLE patients reacts with cardiolipin/beta 2-GP1 complex. In order to disclose clinical significance of aCL in patients with SLE, aCL was determined by newly-developed anti-CL.beta 2-GP1 kit [Yamasa] EIA in 58 patients with SLE and the relationship between clinical manifestation of SLE and the presence of aCL was examined. Anti-cardiolipin antibody was positive in 20 patients (34.5%). In 20 SLE patients with positive aCL, livedo reticularis in 7, retinal vein thrombosis in 3, thrombophlebitis in 3 and other vasculo-occlusive episodes were observed as a characteristic clinical features of positive aCL. In contrast, a SLE patient complicated by ileal perforation due to necrotizing angiitis had negative aCL. Other clinical and laboratory features associated with aCL include recurrent fetal loss and thrombocytopenia.",

author = "K. Aoki and T. Takeuchi and I. Itoh and Y. Takano and T. Itoh and O. Hosono and J. Koide and T. Abe",

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AU - Aoki, K.

AU - Takeuchi, T.

AU - Itoh, I.

AU - Takano, Y.

AU - Itoh, T.

AU - Hosono, O.

AU - Koide, J.

AU - Abe, T.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 1994/12

Y1 - 1994/12

N2 - Anti-cardiolipin antibody (aCL) in SLE patients reacts with cardiolipin/beta 2-GP1 complex. In order to disclose clinical significance of aCL in patients with SLE, aCL was determined by newly-developed anti-CL.beta 2-GP1 kit [Yamasa] EIA in 58 patients with SLE and the relationship between clinical manifestation of SLE and the presence of aCL was examined. Anti-cardiolipin antibody was positive in 20 patients (34.5%). In 20 SLE patients with positive aCL, livedo reticularis in 7, retinal vein thrombosis in 3, thrombophlebitis in 3 and other vasculo-occlusive episodes were observed as a characteristic clinical features of positive aCL. In contrast, a SLE patient complicated by ileal perforation due to necrotizing angiitis had negative aCL. Other clinical and laboratory features associated with aCL include recurrent fetal loss and thrombocytopenia.

AB - Anti-cardiolipin antibody (aCL) in SLE patients reacts with cardiolipin/beta 2-GP1 complex. In order to disclose clinical significance of aCL in patients with SLE, aCL was determined by newly-developed anti-CL.beta 2-GP1 kit [Yamasa] EIA in 58 patients with SLE and the relationship between clinical manifestation of SLE and the presence of aCL was examined. Anti-cardiolipin antibody was positive in 20 patients (34.5%). In 20 SLE patients with positive aCL, livedo reticularis in 7, retinal vein thrombosis in 3, thrombophlebitis in 3 and other vasculo-occlusive episodes were observed as a characteristic clinical features of positive aCL. In contrast, a SLE patient complicated by ileal perforation due to necrotizing angiitis had negative aCL. Other clinical and laboratory features associated with aCL include recurrent fetal loss and thrombocytopenia.

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Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE)

Abstract

ASJC Scopus subject areas

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