Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE)

K. Aoki, Tsutomu Takeuchi, I. Itoh, Y. Takano, T. Itoh, O. Hosono, J. Koide, T. Abe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Anti-cardiolipin antibody (aCL) in SLE patients reacts with cardiolipin/beta 2-GP1 complex. In order to disclose clinical significance of aCL in patients with SLE, aCL was determined by newly-developed anti-CL.beta 2-GP1 kit [Yamasa] EIA in 58 patients with SLE and the relationship between clinical manifestation of SLE and the presence of aCL was examined. Anti-cardiolipin antibody was positive in 20 patients (34.5%). In 20 SLE patients with positive aCL, livedo reticularis in 7, retinal vein thrombosis in 3, thrombophlebitis in 3 and other vasculo-occlusive episodes were observed as a characteristic clinical features of positive aCL. In contrast, a SLE patient complicated by ileal perforation due to necrotizing angiitis had negative aCL. Other clinical and laboratory features associated with aCL include recurrent fetal loss and thrombocytopenia.

Original languageEnglish
Pages (from-to)961-966
Number of pages6
JournalRyumachi
Volume34
Issue number6
Publication statusPublished - 1994 Dec
Externally publishedYes

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Cardiolipins
Systemic Lupus Erythematosus
Anti-Idiotypic Antibodies
Livedo Reticularis
Retinal Vein Occlusion
Thrombophlebitis
Vasculitis
Thrombocytopenia

ASJC Scopus subject areas

  • Rheumatology

Cite this

Aoki, K., Takeuchi, T., Itoh, I., Takano, Y., Itoh, T., Hosono, O., ... Abe, T. (1994). Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE). Ryumachi, 34(6), 961-966.

Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE). / Aoki, K.; Takeuchi, Tsutomu; Itoh, I.; Takano, Y.; Itoh, T.; Hosono, O.; Koide, J.; Abe, T.

In: Ryumachi, Vol. 34, No. 6, 12.1994, p. 961-966.

Research output: Contribution to journalArticle

Aoki, K, Takeuchi, T, Itoh, I, Takano, Y, Itoh, T, Hosono, O, Koide, J & Abe, T 1994, 'Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE)', Ryumachi, vol. 34, no. 6, pp. 961-966.
Aoki, K. ; Takeuchi, Tsutomu ; Itoh, I. ; Takano, Y. ; Itoh, T. ; Hosono, O. ; Koide, J. ; Abe, T. / Clinical significance of anti-cardiolipin antibody in patients with systemic lupus erythematosus (SLE). In: Ryumachi. 1994 ; Vol. 34, No. 6. pp. 961-966.
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