Clinical significance of extrahepatic bile duct resection for advanced gallbladder cancer

Yoshihiro Sakamoto, Tomoo Kosuge, Kazuaki Shimada, Tsuyoshi Sano, Taizo Hibi, Junji Yamamoto, Tadatoshi Takayama, Masatoshi Makuuchi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background and Objectives: The aim of this study was to determine the clinical significance of extrahepatic bile duct (EHBD) resection during surgery for advanced gallbladder cancer. Methods: Among 110 patients with pT2 or higher grade gallbladder cancer, 58 patients without microscopic invasion to the EHBD were reviewed. Prognostic factors of the 58 patients were evaluated by multivariate analysis. The impact of EHBD resection on survival was assessed in relation to two prognostic determinants: (i) lymph node metastasis: positive (n = 23) and negative (n = 35); (ii) perineural invasion: positive (n = 25) and negative (n = 33). Results: Hepatic metastasis and perineural invasion were found to be independently significant prognostic factors. (i) No survival benefit of additional EHBD resection could be confirmed in each group of patients with or without nodal metastasis. (ii) In 25 patients with perineural invasion, 14 patients who underwent EHBD resection showed better survival as compared to the 11 patients who did not undergo EHBD resection (5-year survival rate, 46% vs. 0%, P = 0.009). In the remaining 33 patients without perineural invasion, the additional EHBD resection did not yield significant improvement of survival (P = 0.28). Conclusions: Resection of EHBD may offer prognostic advantage when perineural invasion exists, even in the absence of biliary infiltration.

Original languageEnglish
Pages (from-to)298-306
Number of pages9
JournalJournal of Surgical Oncology
Volume94
Issue number4
DOIs
Publication statusPublished - 2006 Sep 15
Externally publishedYes

Fingerprint

Gallbladder Neoplasms
Extrahepatic Bile Ducts
Survival
Neoplasm Metastasis
Multivariate Analysis
Survival Rate
Lymph Nodes
Liver

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Sakamoto, Y., Kosuge, T., Shimada, K., Sano, T., Hibi, T., Yamamoto, J., ... Makuuchi, M. (2006). Clinical significance of extrahepatic bile duct resection for advanced gallbladder cancer. Journal of Surgical Oncology, 94(4), 298-306. https://doi.org/10.1002/jso.20585

Clinical significance of extrahepatic bile duct resection for advanced gallbladder cancer. / Sakamoto, Yoshihiro; Kosuge, Tomoo; Shimada, Kazuaki; Sano, Tsuyoshi; Hibi, Taizo; Yamamoto, Junji; Takayama, Tadatoshi; Makuuchi, Masatoshi.

In: Journal of Surgical Oncology, Vol. 94, No. 4, 15.09.2006, p. 298-306.

Research output: Contribution to journalArticle

Sakamoto, Y, Kosuge, T, Shimada, K, Sano, T, Hibi, T, Yamamoto, J, Takayama, T & Makuuchi, M 2006, 'Clinical significance of extrahepatic bile duct resection for advanced gallbladder cancer', Journal of Surgical Oncology, vol. 94, no. 4, pp. 298-306. https://doi.org/10.1002/jso.20585
Sakamoto, Yoshihiro ; Kosuge, Tomoo ; Shimada, Kazuaki ; Sano, Tsuyoshi ; Hibi, Taizo ; Yamamoto, Junji ; Takayama, Tadatoshi ; Makuuchi, Masatoshi. / Clinical significance of extrahepatic bile duct resection for advanced gallbladder cancer. In: Journal of Surgical Oncology. 2006 ; Vol. 94, No. 4. pp. 298-306.
@article{743d567572a24fb4bd0663e12089b219,
title = "Clinical significance of extrahepatic bile duct resection for advanced gallbladder cancer",
abstract = "Background and Objectives: The aim of this study was to determine the clinical significance of extrahepatic bile duct (EHBD) resection during surgery for advanced gallbladder cancer. Methods: Among 110 patients with pT2 or higher grade gallbladder cancer, 58 patients without microscopic invasion to the EHBD were reviewed. Prognostic factors of the 58 patients were evaluated by multivariate analysis. The impact of EHBD resection on survival was assessed in relation to two prognostic determinants: (i) lymph node metastasis: positive (n = 23) and negative (n = 35); (ii) perineural invasion: positive (n = 25) and negative (n = 33). Results: Hepatic metastasis and perineural invasion were found to be independently significant prognostic factors. (i) No survival benefit of additional EHBD resection could be confirmed in each group of patients with or without nodal metastasis. (ii) In 25 patients with perineural invasion, 14 patients who underwent EHBD resection showed better survival as compared to the 11 patients who did not undergo EHBD resection (5-year survival rate, 46{\%} vs. 0{\%}, P = 0.009). In the remaining 33 patients without perineural invasion, the additional EHBD resection did not yield significant improvement of survival (P = 0.28). Conclusions: Resection of EHBD may offer prognostic advantage when perineural invasion exists, even in the absence of biliary infiltration.",
author = "Yoshihiro Sakamoto and Tomoo Kosuge and Kazuaki Shimada and Tsuyoshi Sano and Taizo Hibi and Junji Yamamoto and Tadatoshi Takayama and Masatoshi Makuuchi",
year = "2006",
month = "9",
day = "15",
doi = "10.1002/jso.20585",
language = "English",
volume = "94",
pages = "298--306",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Clinical significance of extrahepatic bile duct resection for advanced gallbladder cancer

AU - Sakamoto, Yoshihiro

AU - Kosuge, Tomoo

AU - Shimada, Kazuaki

AU - Sano, Tsuyoshi

AU - Hibi, Taizo

AU - Yamamoto, Junji

AU - Takayama, Tadatoshi

AU - Makuuchi, Masatoshi

PY - 2006/9/15

Y1 - 2006/9/15

N2 - Background and Objectives: The aim of this study was to determine the clinical significance of extrahepatic bile duct (EHBD) resection during surgery for advanced gallbladder cancer. Methods: Among 110 patients with pT2 or higher grade gallbladder cancer, 58 patients without microscopic invasion to the EHBD were reviewed. Prognostic factors of the 58 patients were evaluated by multivariate analysis. The impact of EHBD resection on survival was assessed in relation to two prognostic determinants: (i) lymph node metastasis: positive (n = 23) and negative (n = 35); (ii) perineural invasion: positive (n = 25) and negative (n = 33). Results: Hepatic metastasis and perineural invasion were found to be independently significant prognostic factors. (i) No survival benefit of additional EHBD resection could be confirmed in each group of patients with or without nodal metastasis. (ii) In 25 patients with perineural invasion, 14 patients who underwent EHBD resection showed better survival as compared to the 11 patients who did not undergo EHBD resection (5-year survival rate, 46% vs. 0%, P = 0.009). In the remaining 33 patients without perineural invasion, the additional EHBD resection did not yield significant improvement of survival (P = 0.28). Conclusions: Resection of EHBD may offer prognostic advantage when perineural invasion exists, even in the absence of biliary infiltration.

AB - Background and Objectives: The aim of this study was to determine the clinical significance of extrahepatic bile duct (EHBD) resection during surgery for advanced gallbladder cancer. Methods: Among 110 patients with pT2 or higher grade gallbladder cancer, 58 patients without microscopic invasion to the EHBD were reviewed. Prognostic factors of the 58 patients were evaluated by multivariate analysis. The impact of EHBD resection on survival was assessed in relation to two prognostic determinants: (i) lymph node metastasis: positive (n = 23) and negative (n = 35); (ii) perineural invasion: positive (n = 25) and negative (n = 33). Results: Hepatic metastasis and perineural invasion were found to be independently significant prognostic factors. (i) No survival benefit of additional EHBD resection could be confirmed in each group of patients with or without nodal metastasis. (ii) In 25 patients with perineural invasion, 14 patients who underwent EHBD resection showed better survival as compared to the 11 patients who did not undergo EHBD resection (5-year survival rate, 46% vs. 0%, P = 0.009). In the remaining 33 patients without perineural invasion, the additional EHBD resection did not yield significant improvement of survival (P = 0.28). Conclusions: Resection of EHBD may offer prognostic advantage when perineural invasion exists, even in the absence of biliary infiltration.

UR - http://www.scopus.com/inward/record.url?scp=33748307401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748307401&partnerID=8YFLogxK

U2 - 10.1002/jso.20585

DO - 10.1002/jso.20585

M3 - Article

VL - 94

SP - 298

EP - 306

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 4

ER -