Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome

Fumio Sakamaki; Akitoshi Ishizaka; Naoki Hasegawa; Tetsuya Urano; Kohichi Sayama; Hidetoshi Nakamura; Takeshi Terashima; Yasuhiro Waki; Sadatomo Tasaka; Seitaro Fujishima; Minoru Kanazawa; Takeo Kawashiro

doi:10.2169/internalmedicine.33.257

Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome

Fumio Sakamaki, Akitoshi Ishizaka, Naoki Hasegawa, Tetsuya Urano, Kohichi Sayama, Hidetoshi Nakamura, Takeshi Terashima, Yasuhiro Waki, Sadatomo Tasaka, Seitaro Fujishima, Minoru Kanazawa, Takeo Kawashiro

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05±0.65 nMol/ml, 7S collagen 9.06±5.96 ng/ml: Mean±SD) were significantly higher than those in the control group (2.54±0.33 and 3.43±1.05, p<0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p<0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS.

Original language	English
Pages (from-to)	257-262
Number of pages	6
Journal	Internal Medicine
Volume	33
Issue number	5
DOIs	https://doi.org/10.2169/internalmedicine.33.257
Publication status	Published - 1994

Keywords

acute lung injury
lung injury score
plasma parameters

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.33.257

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Sakamaki, F., Ishizaka, A., Hasegawa, N., Urano, T., Sayama, K., Nakamura, H., Terashima, T., Waki, Y., Tasaka, S., Fujishima, S., Kanazawa, M., & Kawashiro, T. (1994). Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome. Internal Medicine, 33(5), 257-262. https://doi.org/10.2169/internalmedicine.33.257

Sakamaki, F, Ishizaka, A, Hasegawa, N, Urano, T, Sayama, K, Nakamura, H, Terashima, T, Waki, Y, Tasaka, S, Fujishima, S, Kanazawa, M & Kawashiro, T 1994, 'Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome', Internal Medicine, vol. 33, no. 5, pp. 257-262. https://doi.org/10.2169/internalmedicine.33.257

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abstract = "We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05±0.65 nMol/ml, 7S collagen 9.06±5.96 ng/ml: Mean±SD) were significantly higher than those in the control group (2.54±0.33 and 3.43±1.05, p<0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p<0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS.",

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author = "Fumio Sakamaki and Akitoshi Ishizaka and Naoki Hasegawa and Tetsuya Urano and Kohichi Sayama and Hidetoshi Nakamura and Takeshi Terashima and Yasuhiro Waki and Sadatomo Tasaka and Seitaro Fujishima and Minoru Kanazawa and Takeo Kawashiro",

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AU - Hasegawa, Naoki

AU - Urano, Tetsuya

AU - Sayama, Kohichi

AU - Nakamura, Hidetoshi

AU - Terashima, Takeshi

AU - Waki, Yasuhiro

AU - Tasaka, Sadatomo

AU - Fujishima, Seitaro

AU - Kanazawa, Minoru

AU - Kawashiro, Takeo

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N2 - We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05±0.65 nMol/ml, 7S collagen 9.06±5.96 ng/ml: Mean±SD) were significantly higher than those in the control group (2.54±0.33 and 3.43±1.05, p<0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p<0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS.

AB - We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05±0.65 nMol/ml, 7S collagen 9.06±5.96 ng/ml: Mean±SD) were significantly higher than those in the control group (2.54±0.33 and 3.43±1.05, p<0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p<0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS.

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Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome

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