Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome

Fumio Sakamaki, Akitoshi Ishizaka, Naoki Hasegawa, Tetsuya Urano, Kohichi Sayama, Hidetoshi Nakamura, Takeshi Terashima, Yasuhiro Waki, Sadatomo Tasaka, Seitaro Fujishima, Minoru Kanazawa, Takeo Kawashiro

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05±0.65 nMol/ml, 7S collagen 9.06±5.96 ng/ml: Mean±SD) were significantly higher than those in the control group (2.54±0.33 and 3.43±1.05, p<0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p<0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalInternal Medicine
Volume33
Issue number5
DOIs
Publication statusPublished - 1994 Jan 1

Keywords

  • acute lung injury
  • lung injury score
  • plasma parameters

ASJC Scopus subject areas

  • Internal Medicine

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