Clinical significance of perioperative immunonutrition for patients with esophageal cancer

Hiroya Takeuchi, Shunji Ikeuchi, Yoshiki Kawaguchi, Yuukou Kitagawa, Yoh Isobe, Kiyoshi Kubochi, Masaki Kitajima, Sumio Matsumoto

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: We hypothesized that preoperative and/or postoperative enteral immune-enhanced formulas that are supplemented with arginine, omega-3 fatty acids, and RNA may reduce postoperative complications in patients undergoing esophagectomy for thoracic esophageal squamous cell carcinoma (ESCC). Methods: Forty patients who underwent esophagectomy were divided into three groups: group A (n = 20) received a control enteral diet (Erental) through the jejunostomy after surgery. group B (n = 6) received an enteral diet supplemented with immune-enhancing substrates (Impact) containing arginine, omega-3 fatty acids, and RNA after surgery. group C (n = 14) received the impact before and after surgery. Results: Lymphocyte counts in group C on postoperative day (POD) 7 were somewhat higher than that in group A (p = 0.07) and significantly higher than in group B (p = 0.03). Furthermore the incidence of incisional wound infection in group C was significantly lower than that in group A (p = 0.03). Moreover, the duration of postoperative systemic inflammatory response syndrome (SIRS) was significantly shorter in group C than in group A (p < 0.05). Conclusions: This study reveals that the perioperative immune-enhanced formula may be superior to postoperative control enteral formulas in terms of reducing surgical wound infection and postoperative SIRS, which may result in serious postoperative complications for patients who have undergone esophagectomy.

Original languageEnglish
Pages (from-to)2160-2167
Number of pages8
JournalWorld Journal of Surgery
Volume31
Issue number11
DOIs
Publication statusPublished - 2007 Nov

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Esophageal Neoplasms
Small Intestine
Esophagectomy
Systemic Inflammatory Response Syndrome
Omega-3 Fatty Acids
Arginine
RNA
Diet
Jejunostomy
Surgical Wound Infection
Lymphocyte Count
Wound Infection
Thorax
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Takeuchi, H., Ikeuchi, S., Kawaguchi, Y., Kitagawa, Y., Isobe, Y., Kubochi, K., ... Matsumoto, S. (2007). Clinical significance of perioperative immunonutrition for patients with esophageal cancer. World Journal of Surgery, 31(11), 2160-2167. https://doi.org/10.1007/s00268-007-9219-8

Clinical significance of perioperative immunonutrition for patients with esophageal cancer. / Takeuchi, Hiroya; Ikeuchi, Shunji; Kawaguchi, Yoshiki; Kitagawa, Yuukou; Isobe, Yoh; Kubochi, Kiyoshi; Kitajima, Masaki; Matsumoto, Sumio.

In: World Journal of Surgery, Vol. 31, No. 11, 11.2007, p. 2160-2167.

Research output: Contribution to journalArticle

Takeuchi, H, Ikeuchi, S, Kawaguchi, Y, Kitagawa, Y, Isobe, Y, Kubochi, K, Kitajima, M & Matsumoto, S 2007, 'Clinical significance of perioperative immunonutrition for patients with esophageal cancer', World Journal of Surgery, vol. 31, no. 11, pp. 2160-2167. https://doi.org/10.1007/s00268-007-9219-8
Takeuchi, Hiroya ; Ikeuchi, Shunji ; Kawaguchi, Yoshiki ; Kitagawa, Yuukou ; Isobe, Yoh ; Kubochi, Kiyoshi ; Kitajima, Masaki ; Matsumoto, Sumio. / Clinical significance of perioperative immunonutrition for patients with esophageal cancer. In: World Journal of Surgery. 2007 ; Vol. 31, No. 11. pp. 2160-2167.
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