Clinical significance of pretransplant serum ferritin on the outcome of allogeneic hematopoietic SCT: A prospective cohort study by the Kanto Study Group for Cell Therapy

M. Tanaka, H. Kanamori, K. Matsumoto, T. Tachibana, A. Numata, K. Ohashi, T. Kobayashi, C. Nakaseko, Y. Kanda, E. Yamazaki, S. Fujisawa, J. Ooi, T. Sakura, N. Aotsuka, M. Onoda, S. Machida, J. Kato, K. Usuki, R. Watanabe, J. TaguchiS. Yano, T. Saito, S. Takahashi, H. Sakamaki, S. Okamoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This prospective study aimed to investigate the influence of pretransplant serum ferritin levels on the outcomes of allogeneic hematopoietic SCT (HSCT). In total, 190 patients with acute leukemia or myelodysplastic syndrome were consecutively enrolled. The patients were divided into two groups: low-ferritin group (<1000 ng/mL) and high-ferritin group (≥1000 ng/mL). The primary end point was the cumulative incidence of infection within 100 days after HSCT, which was similar between the two groups: bloodstream infection, 35 vs 38%, P=0.65; bacterial infection, 44 vs 41%, P=0.68; and fungal infection, 6 vs 8%, P=0.71. The 1-year adjusted probability of OS of the high-ferritin group was significantly lower than that of the low-ferritin group (76 vs 63%, P=0.017). Using receiver operating characteristic curve, the threshold of pretransplant serum ferritin levels for bloodstream infection was 1400 ng/mL; the threshold for OS, EFS and non-relapse mortality was 1349 ng/mL. In conclusion, pretransplant serum ferritin levels of ≥1000 ng/mL did not influence the incidence of infection but adversely affected OS after HSCT. A higher threshold of pretransplant serum ferritin levels may predict HSCT outcomes.

Original languageEnglish
Pages (from-to)727-733
Number of pages7
JournalBone Marrow Transplantation
Volume50
Issue number5
DOIs
Publication statusPublished - 2015 May 8

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Clinical significance of pretransplant serum ferritin on the outcome of allogeneic hematopoietic SCT: A prospective cohort study by the Kanto Study Group for Cell Therapy'. Together they form a unique fingerprint.

  • Cite this

    Tanaka, M., Kanamori, H., Matsumoto, K., Tachibana, T., Numata, A., Ohashi, K., Kobayashi, T., Nakaseko, C., Kanda, Y., Yamazaki, E., Fujisawa, S., Ooi, J., Sakura, T., Aotsuka, N., Onoda, M., Machida, S., Kato, J., Usuki, K., Watanabe, R., ... Okamoto, S. (2015). Clinical significance of pretransplant serum ferritin on the outcome of allogeneic hematopoietic SCT: A prospective cohort study by the Kanto Study Group for Cell Therapy. Bone Marrow Transplantation, 50(5), 727-733. https://doi.org/10.1038/bmt.2015.17