Clinical studies on penetration of biapenem to postoperative peritoneal exudate

K. Ishibiki; Y. Saikawa; S. Shibata

Clinical studies on penetration of biapenem to postoperative peritoneal exudate

K. Ishibiki, Y. Saikawa, S. Shibata

Research output: Contribution to journal › Article

Abstract

We studied biapenem (BIPM), a new carbapenem antibiotic, in terms of postoperative penetration into peritoneal exudate. We measured daily concentration of BIPM in peritoneal exudate after radical gastrectomy for gastric cancer or gastric leiomyosarcoma for 3 days. BIPM was administered by intravenous drip infusion at a dose of 0.3 g twice a day. The average concentrations in peritoneal exudate in 3 patients were 0.68, 0.33 and 0.11 μg/ml on days 1, 2 and 3, respectively. No side effects and no abnormal laboratory findings were observed.

Original language	English
Pages (from-to)	683-685
Number of pages	3
Journal	Chemotherapy
Volume	42
Issue number	SUPPL. 4
Publication status	Published - 1994

ASJC Scopus subject areas

Pharmacology

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abstract = "We studied biapenem (BIPM), a new carbapenem antibiotic, in terms of postoperative penetration into peritoneal exudate. We measured daily concentration of BIPM in peritoneal exudate after radical gastrectomy for gastric cancer or gastric leiomyosarcoma for 3 days. BIPM was administered by intravenous drip infusion at a dose of 0.3 g twice a day. The average concentrations in peritoneal exudate in 3 patients were 0.68, 0.33 and 0.11 μg/ml on days 1, 2 and 3, respectively. No side effects and no abnormal laboratory findings were observed.",

author = "K. Ishibiki and Y. Saikawa and S. Shibata",

year = "1994",

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AB - We studied biapenem (BIPM), a new carbapenem antibiotic, in terms of postoperative penetration into peritoneal exudate. We measured daily concentration of BIPM in peritoneal exudate after radical gastrectomy for gastric cancer or gastric leiomyosarcoma for 3 days. BIPM was administered by intravenous drip infusion at a dose of 0.3 g twice a day. The average concentrations in peritoneal exudate in 3 patients were 0.68, 0.33 and 0.11 μg/ml on days 1, 2 and 3, respectively. No side effects and no abnormal laboratory findings were observed.

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