Abstract
We studied biapenem (BIPM), a new carbapenem antibiotic, in terms of postoperative penetration into peritoneal exudate. We measured daily concentration of BIPM in peritoneal exudate after radical gastrectomy for gastric cancer or gastric leiomyosarcoma for 3 days. BIPM was administered by intravenous drip infusion at a dose of 0.3 g twice a day. The average concentrations in peritoneal exudate in 3 patients were 0.68, 0.33 and 0.11 μg/ml on days 1, 2 and 3, respectively. No side effects and no abnormal laboratory findings were observed.
| Original language | English |
|---|---|
| Pages (from-to) | 683-685 |
| Number of pages | 3 |
| Journal | Chemotherapy |
| Volume | 42 |
| Issue number | SUPPL. 4 |
| Publication status | Published - 1994 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Ishibiki, K., Saikawa, Y., & Shibata, S. (1994). Clinical studies on penetration of biapenem to postoperative peritoneal exudate. Chemotherapy, 42(SUPPL. 4), 683-685.