Abstract
We studied biapenem (BIPM), a new carbapenem antibiotic, in terms of postoperative penetration into peritoneal exudate. We measured daily concentration of BIPM in peritoneal exudate after radical gastrectomy for gastric cancer or gastric leiomyosarcoma for 3 days. BIPM was administered by intravenous drip infusion at a dose of 0.3 g twice a day. The average concentrations in peritoneal exudate in 3 patients were 0.68, 0.33 and 0.11 μg/ml on days 1, 2 and 3, respectively. No side effects and no abnormal laboratory findings were observed.
Original language | English |
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Pages (from-to) | 683-685 |
Number of pages | 3 |
Journal | Chemotherapy |
Volume | 42 |
Issue number | SUPPL. 4 |
Publication status | Published - 1994 |
ASJC Scopus subject areas
- Pharmacology