Clinical studies on penetration of biapenem to postoperative peritoneal exudate

K. Ishibiki, Y. Saikawa, S. Shibata

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Abstract

We studied biapenem (BIPM), a new carbapenem antibiotic, in terms of postoperative penetration into peritoneal exudate. We measured daily concentration of BIPM in peritoneal exudate after radical gastrectomy for gastric cancer or gastric leiomyosarcoma for 3 days. BIPM was administered by intravenous drip infusion at a dose of 0.3 g twice a day. The average concentrations in peritoneal exudate in 3 patients were 0.68, 0.33 and 0.11 μg/ml on days 1, 2 and 3, respectively. No side effects and no abnormal laboratory findings were observed.

Original languageEnglish
Pages (from-to)683-685
Number of pages3
JournalChemotherapy
Volume42
Issue numberSUPPL. 4
Publication statusPublished - 1994

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ASJC Scopus subject areas

  • Pharmacology

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Ishibiki, K., Saikawa, Y., & Shibata, S. (1994). Clinical studies on penetration of biapenem to postoperative peritoneal exudate. Chemotherapy, 42(SUPPL. 4), 683-685.