Clinical superinfection and its attendant symptomatic changes in pediatrics

K. Sunakawa, H. Akita, S. Iwata, Y. Sato

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Studies were conducted on the effects of antibiotics on intestinal bacterial flora and symptomatic changes associated with possible superinfection following antibiotic treatment. Following the administration of oral antibiotics, there were no marked changes in the intestinal flora. After second and third-generation cephems were injected, most bacteria, excluding Streptococcus faecalis which is resistant to them, decreased and fungi increased. The incidences of diarrhea after administering oral antibiotics were high for amoxicillin and amoxicillin + clavulanic acid. In some patients with depressed immunity, such as leukemic patients and neonates, decreases in intestinal bacteria after doses of antibiotics led to increases in pathogenic bacteria. They invaded the circulating blood, leading to septicemia. Septicemia originating in the intestinal tract was frequently associated with the development of vitamin K deficiency. Besides changes in the intestinal flora, a decrease in oral food intake and the presence of a methylthiotetrazole group in the structure of the administered antibiotics were also found to play a crucial role in causing vitamin K deficiency

Original languageEnglish
Pages (from-to)S103-S111
Issue number1 Supplement
Publication statusPublished - 1985 Jan

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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