Clinical trials: Noncellular regenerative approaches

Vjura Senthilnathan, Nayaab Punjani, Narihito Nagoshi, Christopher S. Ahuja, Michael G. Fehlings

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter will provide an overview of the current noncellular regenerative therapies used in clinical trials as part of treating spinal cord injury (SCI). These methods include the use of antibodies, growth factors, minerals, drugs, biomaterials, and electrical stimulation, which aim to assist the endogenous regenerative circuitry to promote repair and replacement of cellular loss and axonal discontinuity. Most treatments demonstrate safety and feasibility for implementation in SCI; however, further testing is still required to determine efficacy in different clinical subpopulations. This chapter delves into clinical trial phases one to three, as well as humanitarian device exemption studies, with a focus on those from North America, Europe, Japan, and Australia. The trial objectives, main inclusion criteria, and available published results are examined.

Original languageEnglish
Title of host publicationNeural Repair and Regeneration after Spinal Cord Injury and Spine Trauma
Number of pages28
ISBN (Electronic)9780128198353
ISBN (Print)9780128198360
Publication statusPublished - 2022 Jan 1


  • AIS grade
  • Biomaterials
  • Clinical trials
  • Functional electrical stimulation (FES)
  • Regeneration
  • Small molecules
  • Spinal cord injury (SCI)

ASJC Scopus subject areas

  • Medicine(all)


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